PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES

Title:

PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2017/111042

Kind Code:

A1

Abstract:

The present invention provides a process for preparation of the compound of formula (VI), wherein each symbol is as defined in the specification, without using any intermediate compound showing mutagenicity. The process comprises salt formation of the intermediate compound of formula (I) with acid to enable optical resolution to isolate the intermediate compound of formula (II) in a stereo-selective manner.

Inventors:

ONODERA NAOHIRO (JP)
NOGUCHI KOUICHI (JP)
ANDO SHIGERU (JP)
NAGAMATSU DAIKI (JP)
ISHIBASHI KENICHI (JP)
OCHI SHUNSUKE (JP)
HASEGAWA AIKO (JP)
ODA KATSUO (JP)

Application Number:

PCT/JP2016/088415

Publication Date:

June 29, 2017

Filing Date:

December 22, 2016

Export Citation:

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Assignee:

SHIONOGI & CO (JP)

International Classes:

C07D279/06; C07D417/12

Domestic Patent References:

WO2009151098A1	2009-12-17
WO2011070781A1	2011-06-16
WO2014134341A1	2014-09-04
WO2008133274A1	2008-11-06

Foreign References:

EP2305672A1

2011-04-06

Other References:

"Labeled Compounds", vol. 1, 1987, article "Isotopes in the Physical and Biomedical Sciences"
"RAPID-AUTO", 2006, RIGAKU CORPORATION
SHELDRICK, G. M., ACTA CRYST., vol. A64, 2008, pages 112 - 122
FLACK, H. D., ACTA CRYST., vol. A39, 1983, pages 876 - 881
SPEK, A. L., ACTA CRYST., vol. D65, 2009, pages 148 - 155
JOHNSON, C. K.: "ORTEPII. Report ORNL-5138", 1976, OAK RIDGE NATIONAL LABORATORY

Attorney, Agent or Firm:

SAMEJIMA, Mutsumi et al. (JP)

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