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Title:
PROCESS OF ISOLATING ENANTIOMER COMPONENTS FROM ENANTIOMER MIXTURES BY PARTICLE-SIZE-CONTROLLED CRYSTALLIZATION
Document Type and Number:
WIPO Patent Application WO/2010/012746
Kind Code:
A3
Abstract:
The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving, melting or sedimentation, in particular through sieving.

Inventors:
MAILLARD, David (Jahnstrasse 43, Darmstadt, 64285, DE)
KOLLER, Guntram (Am Martinsrain 32, Klein-umstadt, 64823, DE)
WAKARESKO, Ewgenij (Fabrikstrasse 34, Aschaffenburg, 63739, DE)
GOTTBURG-REININGER, Sabine (Händelstrasse 26, Darmstadt, 64291, DE)
Application Number:
EP2009/059769
Publication Date:
August 05, 2010
Filing Date:
July 28, 2009
Export Citation:
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Assignee:
POXEL (200 avenue Jean Jaurès, Lyon, Lyon, F-69007, FR)
MAILLARD, David (Jahnstrasse 43, Darmstadt, 64285, DE)
KOLLER, Guntram (Am Martinsrain 32, Klein-umstadt, 64823, DE)
WAKARESKO, Ewgenij (Fabrikstrasse 34, Aschaffenburg, 63739, DE)
GOTTBURG-REININGER, Sabine (Händelstrasse 26, Darmstadt, 64291, DE)
International Classes:
C07C33/26; C07B57/00; C07C29/78; C07D251/10
Domestic Patent References:
WO2004089917A2
Other References:
A. COLLET ET AL: "Optical Resolution by Direct crystallization of Enantiomer Mixtures", CHEMICAL REVIEWS, vol. 80, no. 3, 1980, pages 215 - 230, XP002569446
LORENZ H. ET AL: "Crystallization of enantiomers", CHEMICAL ENGINEERING AND PROCESSING, vol. 45, 2006, pages 863 - 873, XP002569447
Attorney, Agent or Firm:
TEZIER HERMAN, Béatrice et al. (Becker & Associes, 25 rue Louis Le Grand, Paris, F-75002, FR)
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