Title:
PROCESS FOR MAKING 5-AZACYTOSINE NUCLEOSIDES AND THEIR DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2010/017547
Kind Code:
A8
Abstract:
A process of synthesizing a 5-azacytosine nucleoside, such as azacitidine and decitabine, comprises coupling a silylated 5-azacytosine with a protected D-ribofuranose of formula in the presence of a sulfonic acid catalyst.
Inventors:
HENSCHKE JULIAN PAUL (GB)
ZHANG XIAOHENG (CN)
WANG LUNGHU
CHEN YUNG FA
ZHANG XIAOHENG (CN)
WANG LUNGHU
CHEN YUNG FA
Application Number:
PCT/US2009/053276
Publication Date:
April 08, 2010
Filing Date:
August 10, 2009
Export Citation:
Assignee:
SCINOPHARM TAIWAN LDT
HENSCHKE JULIAN PAUL (GB)
ZHANG XIAOHENG (CN)
WANG LUNGHU
CHEN YUNG FA
CHAN HARDY (US)
HENSCHKE JULIAN PAUL (GB)
ZHANG XIAOHENG (CN)
WANG LUNGHU
CHEN YUNG FA
CHAN HARDY (US)
International Classes:
C07H19/12; A01N43/04; C07H1/00
Attorney, Agent or Firm:
CHENG, Kent, H. (Pontani Lieberman & Pavane LLP,Suite 1210,551 Fifth Avenu, New York NY, US)
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