Title:
PROCESS FOR THE MANUFACTURE OF TOCYL AND TOCOPHERYL ACYLATES
Document Type and Number:
WIPO Patent Application WO2004096791
Kind Code:
A3
Abstract:
A process for the manufacture of a tocyl acylate or a tocopheryl acylate comprises reacting tocol or a tocopherol with an acylating agent in the presence of a solid heterogeneous Brönsted acid catalyst, said catalyst being an inorganic Brönsted acid on a solid carrier material which comprises silicon dioxide, titanium dioxide or both silicon dioxide and titanium dioxide, or being an organofunctional polysilonaxe featuring sulpho groups, the solid heterogeneous Brönsted acid catalyst further featuring a BET surface area from about 10m<2>/g to about 800 m<2>/g and a pore volume from about 0.1 ml/g to about 2.0 ml/g. The main commercial form of vitamin E, being (all-rac)-alpha-tocopheryl acetate, can be manufactured by acylation of (all-rac)-alpha-tocopherol according to this process.
Inventors:
BONRATH WERNER (DE)
GIRAUDI LISA (FR)
GIRAUDI LISA (FR)
Application Number:
PCT/EP2004/004443
Publication Date:
January 06, 2005
Filing Date:
April 27, 2004
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
BONRATH WERNER (DE)
GIRAUDI LISA (FR)
BONRATH WERNER (DE)
GIRAUDI LISA (FR)
International Classes:
C07D311/72; (IPC1-7): C07D311/72
Domestic Patent References:
| WO2002042286A1 | 2002-05-30 | |||
| WO1998025876A1 | 1998-06-18 |
Foreign References:
| EP0582811A1 | 1994-02-16 | |||
| US5703272A | 1997-12-30 | |||
| EP0997193A1 | 2000-05-03 | |||
| US5922900A | 1999-07-13 | |||
| US3459773A | 1969-08-05 |
Other References:
DATABASE WPI Week 1975, Derwent World Patents Index; AN 1975-02567W, XP002292233
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