Title:
PROCESS FOR MANUFACTURING DIAZEPINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2000069835
Kind Code:
A3
Abstract:
The present invention relates to a process for manufacturing diazepine derivatives of general formula (I) wherein R<1> is lower alkyl and R<2> is hydrogen, or R<1> and R<2> are together -(CH2)n- and n is 2 or 3; R<3> is halogen, lower alkyl, lower alkoxy and m is 0, 1 or 2; R<4> is hydrogen or lower alkyl. The compounds of general formula (I) are valuable intermediate products for the manufacture of imidazo[1,5-a][1,4]diazepine derivatives, like for instance 7-chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one, which diazepine derivatives show excellent psychopharmacological properties as agonists of the central benzodiazepine receptors.
Inventors:
HOFFMANN-EMERY FABIENNE
Application Number:
PCT/EP2000/004033
Publication Date:
March 07, 2002
Filing Date:
May 05, 2000
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
C07D243/14; C07D487/04; (IPC1-7): C07D243/14; C07D487/04
Foreign References:
| EP0059389A1 | 1982-09-08 | |||
| EP0059390A1 | 1982-09-08 | |||
| EP0059386A2 | 1982-09-08 |
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