Title:
PROCESS METHOD FOR SYNTHESIZING 1,5,7-TRIAZABICYCLO[5.5.0]DEC-5-ENE IN AUTOCATALYTIC AMPHIPATHIC MIXED SOLVENT
Document Type and Number:
WIPO Patent Application WO/2019/029561
Kind Code:
A1
Abstract:
A process method for synthesizing 1,5,7-triazabicyclo[5.5.0]dec-5-ene (TBD) in an autocatalytic amphipathic mixed solvent. In the process method in the present invention, di(3-amino propyl)amine and guanidine hydrochloride are used as raw materials, and the TBD is synthesized in the hydrophilic-hydrophobic amphipathic mixed solvent at a high yield by using trace TBD (0.001%-0.005%) as a catalyst. The method has the characteristics that the process operations are simple and convenient, the yield of the target product is high (≥95.0%), and the product purity is high (≥98.0%).
Inventors:
LI HONG (CN)
ZHANG QUANXING (CN)
SUN XIANGQIAN (CN)
HUANG WEI (CN)
JIANG WEI (CN)
PAN BINGCAI (CN)
LI AIMIN (CN)
ZHANG QUANXING (CN)
SUN XIANGQIAN (CN)
HUANG WEI (CN)
JIANG WEI (CN)
PAN BINGCAI (CN)
LI AIMIN (CN)
Application Number:
PCT/CN2018/099368
Publication Date:
February 14, 2019
Filing Date:
August 08, 2018
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
C07D487/04
Domestic Patent References:
| WO2011112596A2 | 2011-09-15 |
Foreign References:
| CN107325102A | 2017-11-07 | |||
| CN103539798A | 2014-01-29 | |||
| CN104844608A | 2015-08-19 | |||
| CN103172639A | 2013-06-26 | |||
| CN103459393A | 2013-12-18 | |||
| CN102665406A | 2012-09-12 |
Other References:
PHUONG-TRINH NGUYEN: "T BD-functionalized mesoporous silica: Synthesis and catalytic activity in corn oil transesterification", MICROPOROUS AND MESOPOROUS MATERIALS, vol. 180, 13 July 2013 (2013-07-13), XP028700946, ISSN: 1387-1811
Attorney, Agent or Firm:
SHENZHEN DISI-ELITE INTELLECTUAL PROPERTY AGENCY (CN)
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