Title:
PROCESS FOR THE OPTICAL RESOLUTION AND RECYCLING OF TOMOXETINE
Document Type and Number:
WIPO Patent Application WO2006004977
Kind Code:
A3
Abstract:
The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.
Inventors:
CASTELLI EUGENIO (IT)
LO MONACO GIUSEPPE (IT)
MANTOVANI SILVIA (IT)
DAVERIO PAOLA (IT)
RIVA PAOLO (IT)
VAILATI ALESSANDRA (IT)
BIANCHI STEFANO (IT)
LO MONACO GIUSEPPE (IT)
MANTOVANI SILVIA (IT)
DAVERIO PAOLA (IT)
RIVA PAOLO (IT)
VAILATI ALESSANDRA (IT)
BIANCHI STEFANO (IT)
Application Number:
PCT/US2005/023421
Publication Date:
April 13, 2006
Filing Date:
June 28, 2005
Export Citation:
Assignee:
TEVA PHARM FINE CHEMICALS SRL (IT)
TEVA PHARMA (US)
CASTELLI EUGENIO (IT)
LO MONACO GIUSEPPE (IT)
MANTOVANI SILVIA (IT)
DAVERIO PAOLA (IT)
RIVA PAOLO (IT)
VAILATI ALESSANDRA (IT)
BIANCHI STEFANO (IT)
TEVA PHARMA (US)
CASTELLI EUGENIO (IT)
LO MONACO GIUSEPPE (IT)
MANTOVANI SILVIA (IT)
DAVERIO PAOLA (IT)
RIVA PAOLO (IT)
VAILATI ALESSANDRA (IT)
BIANCHI STEFANO (IT)
International Classes:
C07C213/06; C07C213/10; C07C217/48
Domestic Patent References:
| WO2000064855A1 | 2000-11-02 |
Foreign References:
| US4777291A | 1988-10-11 | |||
| EP0052492A1 | 1982-05-26 |
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