A PROCESS FOR THE PREPARATION OF 17-HYDROXY-6β,7β;15β,l6β-BISMETHYLENE-17&agr -PREGN-4-ENE-3-ONE-21-CARBOXYLIC ACID &gammad -LACTONE AND KEY-INTERMEDIATES FOR THIS PROCESS

WIPO Patent Application WO/2006/059168

A1

The invention relates to a process for the preparation of 17-hydroxy-6β,7β;15β,16β- bismethylene-17&agr -pregn-4-ene-3-one-21-carboxylic acid &gammad -lactone of formula (I) as well as to key- intermediates for this process.

GALIK GYOERGY (HU)
HORVATH JUDIT (HU)
SOEROES BELA (HU)
MAHO SANDOR (HU)
TUBA ZOLTAN (HU)
BALOGH GABOR (HU)

PCT/HU2005/000111

June 08, 2006

October 11, 2005

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RICHTER GEDEON VEGYESZET (HU)
GALIK GYOERGY (HU)
HORVATH JUDIT (HU)
SOEROES BELA (HU)
MAHO SANDOR (HU)
TUBA ZOLTAN (HU)
BALOGH GABOR (HU)

C07J1/00; C07J53/00

WO1998025948A2	1998-06-18
WO2003082894A2	2003-10-09

K. PETZOLDT ET AL: "A Novel Synthetic Route to the Aldosterone-Antagonist Spironenone", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 22, no. 3, 1983, DEWILEY VCH VERLAG, WEINHEIM., pages 406 - 407, XP002365035
D. BITTLER ET AL: "Synthesis of Spironenone - A Novel Highly Active Aldosterone Antagonist", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 21, no. 9, 1982, DEWILEY VCH VERLAG, WEINHEIM., pages 696 - 697, XP002365036
NORMAN P ET AL: "CONTRACEPTIVE HORMONE REPLACEMENT THERAPY ALDOSTERONE ANTAGONIST PROGESTOGEN", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 25, no. 12, December 2000 (2000-12-01), pages 1247 - 1256, XP000993474, ISSN: 0377-8282

Richter, Gedeon Vegyészeti Gyár RT. (Budapest, HU)

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