Title:
PROCESS FOR THE PREPARATION OF 4-BROMOMETHYL-[1,1'-BIPHENYL]-2'-CARBONITRILE
Document Type and Number:
WIPO Patent Application WO/2011/073703
Kind Code:
A3
Abstract:
Process for the preparation of the compounds of the general formula (I) - where in the formula R represents cyano group, - COOR1
or -CONR2R3 group - where R1, R2 and R3 stand for identical or non-identical substituents chosen from the following atom or groups: hydrogen atom, straight or branched C1-7 alkyl group, C3-6 cycloalkyl group; or in one given case a tetrazolyl group substituted with a C1-4 alkyl group or triphenylmethyl group - wherein a compound of the general formula (II) - where the meaning of R is as defined above - is reacted with one of the following reagent pairs as bromine sources: bromate with hydrogen sulfite, or bromate with pyrosulfite, or bromide with percarbonate, or bromide with perborate, in aqueous-organic binary systems, and optionally the resulting compound of the general formula (I) is isolated from the reaction mixture by a method known per se.
Inventors:
HUSZAR CSABA (HU)
ARVAI GEZA (HU)
HEGEDUS ADRIENN (HU)
ARVAI GEZA (HU)
HEGEDUS ADRIENN (HU)
Application Number:
PCT/HU2010/000141
Publication Date:
August 11, 2011
Filing Date:
December 13, 2010
Export Citation:
Assignee:
SANOFI SA (FR)
HUSZAR CSABA (HU)
ARVAI GEZA (HU)
HEGEDUS ADRIENN (HU)
HUSZAR CSABA (HU)
ARVAI GEZA (HU)
HEGEDUS ADRIENN (HU)
International Classes:
C07C257/04; C07C253/30
Foreign References:
| US20060041147A1 | 2006-02-23 | |||
| US6214999B1 | 2001-04-10 | |||
| US2535131A | 1950-12-26 | |||
| GB2306956A | 1997-05-14 | |||
| GB1563164A | 1980-03-19 |
Attorney, Agent or Firm:
SANOFI-AVENTIS (To u. 1-5, Budapest, HU)
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