Title:
PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED ISOBENZOFURANS
Document Type and Number:
WIPO Patent Application WO2003011846
Kind Code:
A3
Abstract:
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.
Inventors:
DALL ASTA LEONE (IT)
COTTICELLI GIOVANNI (IT)
COTTICELLI GIOVANNI (IT)
Application Number:
PCT/EP2002/008550
Publication Date:
November 27, 2003
Filing Date:
July 29, 2002
Export Citation:
Assignee:
INFOSINT SA (CH)
DALL ASTA LEONE (IT)
COTTICELLI GIOVANNI (IT)
DALL ASTA LEONE (IT)
COTTICELLI GIOVANNI (IT)
International Classes:
A61K31/343; A61P25/24; C07D307/87; C07B57/00; C07C249/12; C07C251/48; C07D307/88; (IPC1-7): C07D307/80; C07C251/42
Domestic Patent References:
| WO2001062754A1 | 2001-08-30 | |||
| WO1998019513A2 | 1998-05-14 | |||
| WO1999030548A2 | 1999-06-24 | |||
| WO2001002383A2 | 2001-01-11 |
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