PROCESS FOR PREPARATION OF 2−OXOCARBOXYLIC ACID ESTERS

Title:

PROCESS FOR PREPARATION OF 2−OXOCARBOXYLIC ACID ESTERS

Document Type and Number:

WIPO Patent Application WO/2003/000638

Kind Code:

A1

Abstract:

A process for the preparation of 2−oxocarboxylic acid esters represented by the general formula (I), characterized by oxidizing a 2−hydroxycarboxylic acid ester represented by the general formula (II) in the presence of a nitroxyl free radical represented by the general formula (II), a hypochlorite, a metal bromide, and water with the pH of the reaction system being kept within the range of 5 to 7: (II) (III) (I) wherein R¹ and R² are each optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted aralkyl&semi and R³ is hydrogen, alkoxyl, aralkyloxy, acyloxy, or hydroxyl.

Inventors:

OKABE FUMIHIKO (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)

Application Number:

PCT/JP2002/006098

Publication Date:

January 03, 2003

Filing Date:

June 19, 2002

Export Citation:

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Assignee:

KURARAY CO (JP)
OKABE FUMIHIKO (JP)
TORIHARA MASAHIRO (JP)
TAMAI YOSHIN (JP)

International Classes:

C07C67/313; (IPC1-7): C07C67/313; C07C69/716; C07C69/738

Foreign References:

EP0412378A1	1991-02-13
JPH11315052A	1999-11-16
JPH11180932A	1999-07-06

Other References:

LEANNA M.R.: "Synthesis of alpha-amino and alpha-alkoxy aldehydes via oxoammonium oxidation", TETRAHEDRON LETTERS, vol. 33, no. 35, 1992, pages 5029 - 5032, XP000605431
See also references of EP 1405841A4

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