Title:
PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/161646
Kind Code:
A3
Abstract:
The present invention relates to novel intermediates, ethyl N-[(2S)-2 -benzyl-3- hydroxypropanoyl]glycinate and ethyl N-[(2S)-2-benzyl-3-{[(4-bromophenyl)sulfonyl] oxy}propanoyl]glycinate, and processes for their preparation. The present invention also relates to a process for producing alvimopan or its pharmaceutically acceptable salt or solvate thereof using these novel intermediates.(A).
Inventors:
TIWARI ANAND PRAKASH (IN)
VERMA SHYAM SUNDER (IN)
SINGH SHRAVAN KUMAR (IN)
SINGH KAPTAN (IN)
PRASAD MOHAN (IN)
VERMA SHYAM SUNDER (IN)
SINGH SHRAVAN KUMAR (IN)
SINGH KAPTAN (IN)
PRASAD MOHAN (IN)
Application Number:
PCT/IB2011/052764
Publication Date:
March 15, 2012
Filing Date:
June 23, 2011
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
TIWARI ANAND PRAKASH (IN)
VERMA SHYAM SUNDER (IN)
SINGH SHRAVAN KUMAR (IN)
SINGH KAPTAN (IN)
PRASAD MOHAN (IN)
TIWARI ANAND PRAKASH (IN)
VERMA SHYAM SUNDER (IN)
SINGH SHRAVAN KUMAR (IN)
SINGH KAPTAN (IN)
PRASAD MOHAN (IN)
International Classes:
C07C231/02; C07C235/12; C07C303/28; C07C309/73
Foreign References:
| CN100383121C | 2008-04-23 | |||
| EP0937710A1 | 1999-08-25 | |||
| EP0657428A1 | 1995-06-14 | |||
| US5250542A | 1993-10-05 | |||
| CN101967118A | 2011-02-09 | |||
| CN102127005A | 2011-07-20 |
Attorney, Agent or Firm:
RANBAXY LABORATORIES LIMITED (Intellectual Property Department600 College Road East, Suite 210, Princeton NJ, US)
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