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Title:
PROCESS FOR THE PREPARATION OF AQ4N
Document Type and Number:
WIPO Patent Application WO2005080314
Kind Code:
A3
Abstract:
A process for the preparation of compound AQ4N of formula (2) or a salt or solvate thereof wherein the said process includes the reaction step: Formula (1), Formula (2), where compound AQ4 of formula (1) is oxidised to compound AQ4N of formula (2) with an oxidising agent at a reaction temperature not exceeding 10°C.

Inventors:
MATTHEWS IAN TIMOTHY WILLIAM (GB)
SCOTT RONALD MICHAEL (GB)
BARRY JOHN FRANCIS (GB)
HUGHES STEPHEN WILLIAM (GB)
HESLIP ANN (GB)
Application Number:
GB2005000496W
Publication Date:
December 01, 2005
Filing Date:
February 11, 2005
Export Citation:
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Assignee:
KUDOS PHARMACEUTICALS LIMITED
MATTHEWS, IAN, TIMOTHY, WILLIAM
SCOTT, RONALD, MICHAEL
BARRY, JOHN, FRANCIS
HUGHES, STEPHEN, WILLIAM
HESLIP, ANN
International Classes:
C07C221/00; C07C291/04; C07C225/36; (IPC1-7): C07C221/00; C07C225/36
Domestic Patent References:
WO2003078387A12003-09-25
Foreign References:
US6320063B12001-11-20
Other References:
LEE H H ET AL: "A LARGE-SCALE SYNTHESIS OF THE BIOREDUCTIVE DRUG 1,4-BIS{[2-(DIMETHYL-AMINO)ETHYL]AMINO}-5,8-DIHYDROXYANTHRACENE-9,10- DIONE BIS-N-OXIDE (AQ4N)", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 19, 1999, pages 2755 - 2758, XP009049380, ISSN: 0300-922X
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