Title:
PROCESS FOR THE PREPARATION OF AROMATIC AMINES
Document Type and Number:
WIPO Patent Application WO2004110976
Kind Code:
A3
Abstract:
There is provided a process for the preparation of aromatic amines of Formula (1): where R is optionally substituted aryl and R is optionally substituted hydrocarbyl, which comprises: (a) reducing a compound of Formula (2): to give a compound of Formula (3): then, (b) reacting a compound of Formula (3) with a leaving group donor, to give a compound of Formula (4); and, (c) reacting a compound of Formula (4) with ammonia to give the compound of Formula (1).
Inventors:
BLACKER ANDREW JOHN (GB)
MARTIN JULIETTE (FR)
MARTIN JULIETTE (FR)
Application Number:
PCT/GB2004/002478
Publication Date:
April 21, 2005
Filing Date:
June 09, 2004
Export Citation:
Assignee:
AVECIA LTD (GB)
BLACKER ANDREW JOHN (GB)
MARTIN JULIETTE (FR)
BLACKER ANDREW JOHN (GB)
MARTIN JULIETTE (FR)
International Classes:
C07C29/143; C07C209/14; C07C209/16; C07C209/88; C07C303/28; C07C309/66; C07C211/30; (IPC1-7): C07C209/14; C07B57/00; C07C29/143; C07C209/16; C07C211/27; C07C309/66
Domestic Patent References:
| WO2000066558A1 | 2000-11-09 | |||
| WO1998042643A1 | 1998-10-01 | |||
| WO1999024410A1 | 1999-05-20 | |||
| WO1986001502A1 | 1986-03-13 |
Foreign References:
| US5767276A | 1998-06-16 | |||
| US6391865B1 | 2002-05-21 |
Other References:
W. H. PIRKLE ET AL.: "High pressure assisted synthesis.", JOURNAL OF ORGANIC CHEMISTRY., vol. 42, no. 18, 1977, USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 3101 - 3103, XP002300103
JAYARAM R. TAGAT ET AL.: "Piperazine-based CCR5 antagonists as HIV-1 inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 21, 2001, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 3343 - 3346, XP002300104
BJÖRN M. NILSSON ET AL.: "Base-Catalysed cyclization of N-propargylamides to Oxazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, 1989, pages 269 - 275, XP002300105
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 02 2 April 2002 (2002-04-02)
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANFURKT AM MAIN, DE; XP002300107
RANU B C ET AL: "Reduction of trihalomethyl carbinols and their acetates, mesylates and tosylates by indium metal", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 43, no. 34, 19 August 2002 (2002-08-19), pages 5993 - 5995, XP004373219, ISSN: 0040-4039
THOMAS M. STEIN ET AL.: "Synthesis and aggregation properties of a new family of amphiphiles with an unusual headgroup topology", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 114, no. 10, 1992, USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 3943 - 3950, XP002300106
JAYARAM R. TAGAT ET AL.: "Piperazine-based CCR5 antagonists as HIV-1 inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 21, 2001, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 3343 - 3346, XP002300104
BJÖRN M. NILSSON ET AL.: "Base-Catalysed cyclization of N-propargylamides to Oxazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, 1989, pages 269 - 275, XP002300105
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 02 2 April 2002 (2002-04-02)
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANFURKT AM MAIN, DE; XP002300107
RANU B C ET AL: "Reduction of trihalomethyl carbinols and their acetates, mesylates and tosylates by indium metal", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 43, no. 34, 19 August 2002 (2002-08-19), pages 5993 - 5995, XP004373219, ISSN: 0040-4039
THOMAS M. STEIN ET AL.: "Synthesis and aggregation properties of a new family of amphiphiles with an unusual headgroup topology", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 114, no. 10, 1992, USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 3943 - 3950, XP002300106
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