Title:
PROCESS FOR THE PREPARATION OF ATOVAQUONE
Document Type and Number:
WIPO Patent Application WO/2012/080243
Kind Code:
A3
Abstract:
Disclosed herein is novel process for preparation of atovaquone, which process includes reacting1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.
Inventors:
DWYER ANDREW NEIL (SG)
GORDON ANDREW (GB)
URQUHART MICHAEL (GB)
GORDON ANDREW (GB)
URQUHART MICHAEL (GB)
Application Number:
PCT/EP2011/072600
Publication Date:
August 16, 2012
Filing Date:
December 13, 2011
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
DWYER ANDREW NEIL (SG)
GORDON ANDREW (GB)
URQUHART MICHAEL (GB)
DWYER ANDREW NEIL (SG)
GORDON ANDREW (GB)
URQUHART MICHAEL (GB)
International Classes:
C07C46/00; C07C50/32; C07C69/78; C07D307/89; C07D311/76
Domestic Patent References:
| WO2010001379A1 | 2010-01-07 | |||
| WO2008122988A1 | 2008-10-16 |
Foreign References:
| US5856362A | 1999-01-05 |
Other References:
BARCIA J C ET AL: "Palladium-catalyzed synthesis of o-acetylbenzoic acids: a new, efficient general route to 2-hydroxy-3-phenyl-1,4-naphthoquinones and indolo[2,3-b]naphthalene-6,11-diones", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 29, 15 July 2002 (2002-07-15), pages 5141 - 5144, XP002567929, ISSN: 0040-4039, [retrieved on 20020609], DOI: 10.1016/S0040-4039(02)00990-5
Attorney, Agent or Firm:
GOFF, Dawn Caroline et al. (Global Patents CN925.1980 Great West Road, Brentford Middlesex TW8 9GS, GB)
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