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Title:
PROCESS FOR THE PREPARATION OF BENZOYL SUBSTITUTED BICYCLIC COMPOUNDS AND CHIRAL BENZOPYRAN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001094333
Kind Code:
A3
Abstract:
Disclosed are processes for coupling amino substituted 2-chromanyl derivatives and benzoyl derivatives via an amide bond, and intermediates for producing platelet aggregation inhibitors and for producing potent platelet aggregation inhibitors. Also disclosed are processes for producing such compounds from chiral intermediates to provide desired enantiomers, and methods for using the compounds as platelet aggregation inhibitors.

Inventors:
ANTOINE LUC (BE)
BOUQUEL PASCAL (FR)
BORGHESE ALFIO (BE)
FISHER MATTHEW (US)
GORISSEN HUGO (BE)
JAKUBOWSKI JOSEPH A (US)
KHAU VIEN V (US)
MARTINELLI MICHAEL (US)
MERSCHAERT ALAIN (BE)
PAAL MICHAEL (DE)
RUHTER GERD (DE)
RYPENS CARINE (FR)
SCHOTTEN THEO (DE)
STENZEL WOLFGANG (DE)
VAN HOECK JEAN-PIERRE (BE)
Application Number:
US0117765W
Publication Date:
June 06, 2002
Filing Date:
June 01, 2001
Export Citation:
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Assignee:
ELI LILLY & COMPANY
ANTOINE, LUC
BOUQUEL, PASCAL
BORGHESE, ALFIO
FISHER, MATTHEW
GORISSEN, HUGO
JAKUBOWSKI, JOSEPH, A.
KHAU, VIEN, V.
MARTINELLI, MICHAEL
MERSCHAERT, ALAIN
PAAL, MICHAEL
RUHTER, GERD
RYPENS, CARINE
SCHOTTEN, THEO
STENZEL, WOLFGANG
VAN HOECK, JEAN-PIERRE
International Classes:
A61K31/353; A61P7/02; A61P9/08; A61P9/10; C07B57/00; C07C257/18; C07D311/58; (IPC1-7): C07D311/58; A61K31/35; C07C257/18
Domestic Patent References:
WO1994029273A11994-12-22
WO1996018602A11996-06-20
Foreign References:
US5731324A1998-03-24
US5273982A1993-12-28
Other References:
M. J. FISHER ET. AL.: "Fused Bicyclic Gly-Asp-beta-Turn Mimics with Specific Affinity for GPIIb-IIIa" JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 23, 18 November 1999 (1999-11-18), pages 4875-89, XP002180361
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