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Patent Searching and Data


Title:
PROCESS FOR THE PREPARATION OF CEPHEM COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2001/016140
Kind Code:
A1
Abstract:
A process for the preparation of 3-alkenylcephem or 3-norcephem compounds represented by general formula (3), characterized by treating a 3-cephem compound of general formula (1) in a solvent with an alkenyl halide of general formula (2), a nickel catalyst, a metal having a standard redox potential of -0.3 (V/SCE) or below , and a compound of a metal having a standard redox potential higher than that of the above metal. Formula (1) (wherein R?1¿ is hydrogen or the like; R?2¿ is hydrogen or the like; R?3¿ is hydrogen or a carboxyl-protecting group; and X is halogeno or the like). (Formula 2) R?4¿-Y wherein R?4¿ is optionally substituted 1-alkenyl; and Y is halogeno. Formula (3) (wherein R?1¿, R?2¿, and R?3¿ are each as defined above; and R?5¿ is hydrogen or optionally substituted 1-alkenyl).

Inventors:
TANAKA HIDEO (JP)
KAMEYAMA YUTAKA (JP)
Application Number:
PCT/JP2000/005851
Publication Date:
March 08, 2001
Filing Date:
August 30, 2000
Export Citation:
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Assignee:
OTSUKA KAGAKU KK (JP)
TANAKA HIDEO (JP)
KAMEYAMA YUTAKA (JP)
International Classes:
B01J31/30; C07B61/00; C07D501/00; C07D501/04; C07D501/16; C07D501/22; C07D501/24; (IPC1-7): C07D501/04
Foreign References:
GB1391437A1975-04-23
JPS543087A1979-01-11
EP0431794A21991-06-12
Other References:
See also references of EP 1209160A4
Attorney, Agent or Firm:
Tamura, Iwao (Terauchi 1-chome Toyonaka-shi, Osaka, JP)
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