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Title:
PROCESS FOR THE PREPARATION OF CEPHRADINE
Document Type and Number:
WIPO Patent Application WO2005003367
Kind Code:
A3
Abstract:
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70 %, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine = (nCEF/ n7-ADCA) *100%, wherein nCEF=quantity of cephradine formed (in mole); and n7-ADCA =total quantity of 7-ADCA added to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: - reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; - preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050.

Inventors:
LENHARDT CARLOS ENRIQUE (ES)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
Application Number:
PCT/EP2004/007291
Publication Date:
May 26, 2005
Filing Date:
July 01, 2004
Export Citation:
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Assignee:
DSM IP ASSETS BV (NL)
LENHARDT CARLOS ENRIQUE (ES)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
International Classes:
C07D501/00; C12P35/04; (IPC1-7): C12P35/04; C07D501/00; C12N9/84; C12N11/04
Domestic Patent References:
WO1997004086A11997-02-06
WO1999024441A11999-05-20
WO1998056944A11998-12-17
WO1996002663A11996-02-01
WO1999031109A11999-06-24
WO2003055998A22003-07-10
WO1991000865A11991-01-24
WO2003055892A12003-07-10
Foreign References:
US4073687A1978-02-14
US5034522A1991-07-23
US3819620A1974-06-25
US3485819A1969-12-23
EP0997199A12000-05-03
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