Title:
PROCESS FOR THE PREPARATION OF CEPHRADINE
Document Type and Number:
WIPO Patent Application WO2005003367
Kind Code:
A3
Abstract:
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70 %, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine = (nCEF/ n7-ADCA) *100%, wherein nCEF=quantity of cephradine formed (in mole); and n7-ADCA =total quantity of 7-ADCA added to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: - reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; - preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050.
Inventors:
LENHARDT CARLOS ENRIQUE (ES)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
Application Number:
PCT/EP2004/007291
Publication Date:
May 26, 2005
Filing Date:
July 01, 2004
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
LENHARDT CARLOS ENRIQUE (ES)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
LENHARDT CARLOS ENRIQUE (ES)
MOODY HAROLD MONRO (NL)
DOOREN VAN THEODORUS JOHANNES (NL)
HEEMSKERK DENNIS (NL)
HOGENBOOM ANJA GERARDA MARGARE (NL)
International Classes:
C07D501/00; C12P35/04; (IPC1-7): C12P35/04; C07D501/00; C12N9/84; C12N11/04
Domestic Patent References:
WO1997004086A1 | 1997-02-06 | |||
WO1999024441A1 | 1999-05-20 | |||
WO1998056944A1 | 1998-12-17 | |||
WO1996002663A1 | 1996-02-01 | |||
WO1999031109A1 | 1999-06-24 | |||
WO2003055998A2 | 2003-07-10 | |||
WO1991000865A1 | 1991-01-24 | |||
WO2003055892A1 | 2003-07-10 |
Foreign References:
US4073687A | 1978-02-14 | |||
US5034522A | 1991-07-23 | |||
US3819620A | 1974-06-25 | |||
US3485819A | 1969-12-23 | |||
EP0997199A1 | 2000-05-03 |
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