PROCESS FOR THE PREPARATION OF FLUOROATHENYLTHIO HETEROCYCLIC DERIVATIVES

Title:

PROCESS FOR THE PREPARATION OF FLUOROATHENYLTHIO HETEROCYCLIC DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1995/004727

Kind Code:

A1

Abstract:

A process for the preparation of a compound of formula (I) : HetSCH2CH2CH=CF2 wherein Het is an optionally substituted 5- or 6-membered heterocyclic ring, which comprises reacting a compound of formula (II) : HetSH with a compound of formula (III) : CF2=CHCH2CH2L wherein L is chlorine or bromine or a group -OSO2Ra wherein Ra is a C1-4 alkyl group or a phenyl group optionally substituted by a C1-4 alkyl group.

Inventors:

TURNBULL MICHAEL DRYSDALE (GB)
WILLETTS NIGEL JAMES (GB)
FITZJOHN STEVEN (GB)
KHOLIA PRAFULA GOVIND (GB)
SMITH ALISON MARY (GB)
SALMON ROGER (GB)
BANSAL HARJINDER SINGH (GB)
WILLIAMS ALFRED GLYN (GB)

Application Number:

PCT/GB1994/001570

Publication Date:

February 16, 1995

Filing Date:

July 20, 1994

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Assignee:

ZENECA LTD (GB)
TURNBULL MICHAEL DRYSDALE (GB)
WILLETTS NIGEL JAMES (GB)
FITZJOHN STEVEN (GB)
KHOLIA PRAFULA GOVIND (GB)
SMITH ALISON MARY (GB)
SALMON ROGER (GB)
BANSAL HARJINDER SINGH (GB)
WILLIAMS ALFRED GLYN (GB)

International Classes:

C07C17/087; C07C17/23; C07C21/18; C07C309/73; C07D239/38; C07D263/58; C07D277/74; (IPC1-7): C07D263/58; C07D239/38; C07D277/74; C07C21/18; C07C309/73

Foreign References:

GB2270688A	1994-03-23
GB2270689A	1994-03-23

Other References:

CHEMICAL ABSTRACTS, vol. 119, no. 9, 30 August 1993, Columbus, Ohio, US; abstract no. 94942j, page 1035;

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