Title:
PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/002741
Kind Code:
A2
Abstract:
The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2-N-O-R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
Inventors:
JU HYUN (KR)
JOUNG SANG-SUN (KR)
YI HYUN-JIK (KR)
KHOO JA-HEOUK (KR)
LIM JONG-CHUL (KR)
KIM JAE-GYU (KR)
JOUNG SANG-SUN (KR)
YI HYUN-JIK (KR)
KHOO JA-HEOUK (KR)
LIM JONG-CHUL (KR)
KIM JAE-GYU (KR)
Application Number:
PCT/KR2011/004783
Publication Date:
January 05, 2012
Filing Date:
June 30, 2011
Export Citation:
Assignee:
YUHAN CORP (KR)
JU HYUN (KR)
JOUNG SANG-SUN (KR)
YI HYUN-JIK (KR)
KHOO JA-HEOUK (KR)
LIM JONG-CHUL (KR)
KIM JAE-GYU (KR)
JU HYUN (KR)
JOUNG SANG-SUN (KR)
YI HYUN-JIK (KR)
KHOO JA-HEOUK (KR)
LIM JONG-CHUL (KR)
KIM JAE-GYU (KR)
International Classes:
C07D405/06; A61K31/443; C07D239/18
Foreign References:
| US20100029940A1 | 2010-02-04 | |||
| US20080161560A1 | 2008-07-03 | |||
| US20060149065A1 | 2006-07-06 |
Other References:
None
See also references of EP 2588474A4
See also references of EP 2588474A4
Attorney, Agent or Firm:
OH, Kook-Jin (1708-6Seocho-dong, Seocho-gu, Seoul 137-884, KR)
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Claims: