PROCESS FOR THE PREPARATION OF AN IMINE INTERMEDIATE

WIPO Patent Application WO2005007611

A3

The invention is directed to a process for the preparation of [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula (I) by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalene-l-one of the Formula (II) with monomethyl amine which comprises carrying out the reaction in the presence of thionyl chloride in an ether-type solvent. The [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula I is a valuable pharmaceutical intermediate.

BARKOCZY JOZSEF (HU)
KOTAY NAGY PETER (HU)
SIMIG GYULA (HU)
JAKFALVI ELEMER (HU)
GREGORNE BOROS LIVIA (HU)
KRASZNAI GYOERGY (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NAGY KALMAN (HU)
MEMETH NORBERT (HU)

PCT/HU2004/000078

March 24, 2005

July 19, 2004

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EGYT GYOGYSZERVEGYESZETI GYAR (HU)
BARKOCZY JOZSEF (HU)
KOTAY NAGY PETER (HU)
SIMIG GYULA (HU)
JAKFALVI ELEMER (HU)
GREGORNE BOROS LIVIA (HU)
KRASZNAI GYOERGY (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NAGY KALMAN (HU)
MEMETH NORBERT (HU)

C07C209/00; C07C209/26; C07C211/38; C07C211/42; C07C249/02; C07C251/20; (IPC1-7): C07C249/02; C07C209/26; C07C251/20; C07C211/42

US4536518A	1985-08-20
EP1059287A1	2000-12-13

JAESOOK YUN ET AL.: "EFFICIENT KINETIC RESOLUTION IN THE ASYMMETRIC HYDROSILYLATION OF IMINES OF 3-SUBSTITUTED INDANONES AND 4-SUBSTITUTED TETRALONES", J.ORG.CHEM. 65, 2000, pages 767 - 774, XP001204903

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