Title:
PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY
Document Type and Number:
WIPO Patent Application WO2003076629
Kind Code:
A3
Abstract:
The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of the microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which at least one or more of the genes selected from the group comprising aldA, aldB, aldH and betB, or nucleotide sequences that code for them, is/are enhanced, in particular over-expressed, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid.
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Inventors:
RIEPING MECHTHILD (DE)
HERMANN THOMAS (DE)
FARWICK MIKE (DE)
HERMANN THOMAS (DE)
FARWICK MIKE (DE)
Application Number:
PCT/EP2003/001996
Publication Date:
February 05, 2004
Filing Date:
February 27, 2003
Export Citation:
Assignee:
DEGUSSA (DE)
RIEPING MECHTHILD (DE)
HERMANN THOMAS (DE)
FARWICK MIKE (DE)
RIEPING MECHTHILD (DE)
HERMANN THOMAS (DE)
FARWICK MIKE (DE)
International Classes:
C12N9/02; C12N15/53; C12P13/04; C12P13/08; (IPC1-7): C12N15/53; C12N9/02; C12P13/08; C12P13/04
Domestic Patent References:
| WO2001016346A1 | 2001-03-08 | |||
| WO2000061723A1 | 2000-10-19 | |||
| WO1999053035A1 | 1999-10-21 |
Foreign References:
| EP0994190A2 | 2000-04-19 | |||
| DE3823451A1 | 1990-01-18 | |||
| US4278765A | 1981-07-14 | |||
| EP0643135A1 | 1995-03-15 |
Other References:
HIDALGO E ET AL.: "Molecular cloning and DNA sequencing of the Escherichia coli K-12 ald gene encoding aldehyde dehydrogenase", JOURNAL OF BACTERIOLOGY, vol. 173, no. 19, October 1991 (1991-10-01), pages 6118 - 6123, XP008015902, ISSN: 0021-9193
MICHAL G: "Biochemical pathways: an atlas of biochemistry and molecular biology", 1999, JOHN WILEY & SONS INC. AND SPEKTRUM AKADEMISCHER VERLAG, NEW YORK - HEIDELBERG, ISBN: 0-471-33130-9, XP002242199
KRAEMER R: "Genetic and physiological approaches for the production of amino acids", JOURNAL OF BIOTECHNOLOGY, vol. 45, no. 1, 1996, pages 1 - 21, XP002178648, ISSN: 0168-1656
JETTEN M S M ET AL.: "Recent advances in the physiology and genetics of amino acid-producing bacteria.", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 15, no. 1, 1995, pages 73 - 103, XP000613291, ISSN: 0738-8551
MICHAL G: "Biochemical pathways: an atlas of biochemistry and molecular biology", 1999, JOHN WILEY & SONS INC. AND SPEKTRUM AKADEMISCHER VERLAG, NEW YORK - HEIDELBERG, ISBN: 0-471-33130-9, XP002242199
KRAEMER R: "Genetic and physiological approaches for the production of amino acids", JOURNAL OF BIOTECHNOLOGY, vol. 45, no. 1, 1996, pages 1 - 21, XP002178648, ISSN: 0168-1656
JETTEN M S M ET AL.: "Recent advances in the physiology and genetics of amino acid-producing bacteria.", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 15, no. 1, 1995, pages 73 - 103, XP000613291, ISSN: 0738-8551
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