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Title:
PROCESS FOR PREPARATION OF OPTICALLY ACTIVE SULFONAMIDES AND INTERMEDIATES FOR THEIR SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2002/032859
Kind Code:
A1
Abstract:
A process for preparing a diastereomer of a compound represented by the general formula (I) wherein the asymmetric carbon atom of R?1¿ or R?2¿ takes R- or S-configuration, or a salt thereof, characterized by resolving a mixture of diastereomers of the compound or salts of them: (I) wherein R?1¿ and R?2¿ are each independently optionally substituted hydrocarbyl or an optionally substituted heterocyclic group, with the proviso that only one of R?1¿ and R?2¿ contains one asymmetric carbon atom; and R?a¿ is an optically active hydrocarbon group which may be substituted or an optically active heterocyclic group which may be substituted.

Inventors:
Ikemoto, Tomomi (11-5, Yamamotomaruhashi 2-chome Takarazuka-shi, Hyogo, 665-0815, JP)
Nishiguchi, Atsuko (151 Minamisuzuhara 3-chome Itami-shi, Hyogo, Hyogo, 664-0883, JP)
Tomimatsu, Kiminori (12-12-A1002, Nishijuku 2-chome Minoo-shi, Osaka, 562-0034, JP)
Application Number:
PCT/JP2001/009120
Publication Date:
April 25, 2002
Filing Date:
October 17, 2001
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES, LTD. (1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka, 540-8645, JP)
Ikemoto, Tomomi (11-5, Yamamotomaruhashi 2-chome Takarazuka-shi, Hyogo, 665-0815, JP)
Nishiguchi, Atsuko (151 Minamisuzuhara 3-chome Itami-shi, Hyogo, Hyogo, 664-0883, JP)
Tomimatsu, Kiminori (12-12-A1002, Nishijuku 2-chome Minoo-shi, Osaka, 562-0034, JP)
International Classes:
C07C311/51; C07B57/00; C07C303/40; C07C303/44; C07C311/14; C07C311/28; (IPC1-7): C07C311/51; C07C311/14; C07C311/28; C07C303/40; C07B57/00
Domestic Patent References:
WO1995009151A11995-04-06
WO1999046242A11999-09-16
WO1999046242A11999-09-16
Foreign References:
JPH11147873A1999-06-02
JPH08198840A1996-08-06
Other References:
"Kagaku sousetsu no.4 fusai hannou no kagaku", NIPPON KAGAKUKAI EDITION, 15 May 1974 (1974-05-15), GAKKAI SHUPPAN CENTER, pages 242, XP002908275
See also references of EP 1334966A4
Attorney, Agent or Firm:
Takashima, Hajime (Fujimura Yamato Seimei Bldg. 2-14, Fushimimachi 4-chome Chuo-ku Osaka-shi, Osaka, 541-0044, JP)
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