Title:
PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2010/070371
Kind Code:
A8
Abstract:
The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3- dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of formula (I) by reacting the compound of formula (III) with a carbamoylchloride of formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100 °C in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.
Inventors:
AGAINE CSONGOR EVA (HU)
CZIBULA LASZLO (HU)
SEBOK FERENC (HU)
JUHASZ BALINT (HU)
GALAMBOS JANOS (HU)
NOGRADI KATALIN (HU)
CZIBULA LASZLO (HU)
SEBOK FERENC (HU)
JUHASZ BALINT (HU)
GALAMBOS JANOS (HU)
NOGRADI KATALIN (HU)
Application Number:
PCT/HU2009/000110
Publication Date:
April 28, 2011
Filing Date:
December 18, 2009
Export Citation:
Assignee:
RICHTER GEDEON NYRT (HU)
AGAINE CSONGOR EVA (HU)
CZIBULA LASZLO (HU)
SEBOK FERENC (HU)
JUHASZ BALINT (HU)
GALAMBOS JANOS (HU)
NOGRADI KATALIN (HU)
AGAINE CSONGOR EVA (HU)
CZIBULA LASZLO (HU)
SEBOK FERENC (HU)
JUHASZ BALINT (HU)
GALAMBOS JANOS (HU)
NOGRADI KATALIN (HU)
International Classes:
C07D295/135
Attorney, Agent or Firm:
RICHTER GEDEON NYRT. (Budapest, HU)
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