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Title:
PROCESS FOR THE PREPARATION OF POLY(ALKYLENE OXIDE) DERIVATIVES FOR MODIFICATION OF BIOLOGICALLY ACTIVE MOLECULES AND MATERIALS
Document Type and Number:
WIPO Patent Application WO/2012/003045
Kind Code:
A3
Abstract:
A a method for producing activated linear polymers and activatable branched polymers thereof, is carried out by a) reacting a linear nonpeptidic activatable polymer, chemically blocked at one end, with an azole ring activating group that provides a leaving group to produce an intermediate polymer of the general formula poly-lm; b) reacting said poly-lm with an alkylating agent to form an imidazolium salt of the general formula poly-lm+(alkyl)X-; and c) reacting said poly-lm +(alkyl)Xwith a linker molecule bearing at least two nucleophilic moieties to produce an activatable branched polymer derivative thereof. In some embodiments "poly" is a polymer selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), poly(olefinic alcohols), and polymers of alkylene oxide and propylene oxide; in some embodiments "Im +" is an imidazolium ion; and in some embodiments "X-" is an anionic counterion.

Inventors:
VAILLARD SANTIAGO EDUARDO (AR)
GONZALEZ MARIANELA (AR)
GRAU RICARDO JOSE ANTONIO (AR)
Application Number:
PCT/US2011/035733
Publication Date:
February 23, 2012
Filing Date:
May 09, 2011
Export Citation:
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Assignee:
HORIAN AMERICA CORP (US)
VAILLARD SANTIAGO EDUARDO (AR)
GONZALEZ MARIANELA (AR)
GRAU RICARDO JOSE ANTONIO (AR)
International Classes:
A61K9/00; C08G64/00
Foreign References:
US20100038297A12010-02-18
US20090060859A12009-03-05
US20050271727A12005-12-08
Attorney, Agent or Firm:
MYERS BIGEL SIBLEY & SAJOVEC, P.A. (Raleigh, North Carolina, US)
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