Title:
PROCESS FOR THE PREPARATION OF PURE CITALOPRAM
Document Type and Number:
WIPO Patent Application WO2001047877
Kind Code:
A3
Abstract:
A process for the preparation of citalopram of formula (I) in which a compound of formula (II) wherein Z is iodo, bromo, chloro or CF3-(CF2)n-SO2-O- n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process; the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof.
Inventors:
CASTELLIN ANDREA (IT)
VOLPE GIULIO (IT)
SBROGIO FEDERICO (IT)
VOLPE GIULIO (IT)
SBROGIO FEDERICO (IT)
Application Number:
PCT/DK2001/000148
Publication Date:
December 27, 2001
Filing Date:
March 07, 2001
Export Citation:
Assignee:
LUNDBECK & CO AS H (DK)
CASTELLIN ANDREA (IT)
VOLPE GIULIO (IT)
SBROGIO FEDERICO (IT)
CASTELLIN ANDREA (IT)
VOLPE GIULIO (IT)
SBROGIO FEDERICO (IT)
International Classes:
A61P25/24; C07D307/87; (IPC1-7): C07D307/87
Foreign References:
| US4136193A | 1979-01-23 |
Other References:
PROF. DR. E. BARTHOLOME ET AL.: "Ullmanns Encyklopadie der technischen Chemie", VERLAG CHEMIE, WEINHEIM/BERGSTR., XP002946371
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