Title:
PROCESS FOR THE PREPARATION AND PURIFICATION OF 2-(ALKOXYALKYLIDENE)-3-KETOALKANOIC ACID ESTERS FROM 3-KETOALKANOIC ACID ESTERS
Document Type and Number:
WIPO Patent Application WO2005007608
Kind Code:
A3
Abstract:
In its several embodiments, this invention discloses a novel process to prepare the compounds of Formula 3, wherein R<1> is lower alkyl, and R<2> and R<3> can be the same or different, each being independently selected from the group consisting of alkyl, aryl and aralkyl; said process being carried out in a suitable solvent with at least one tert-amine carboxylate salt catalyst. The compounds of formula 3 are chemical intermediates useful for the synthesis of various heterocyclic compounds. These heterocyclic compounds are in turn useful precursors for diverse pharmaceutical, herbicidal and insecticidal agents. In particular, these intermediates are useful precursors to a variety of CCR5 inhibitors.
Inventors:
DRAPER RICHARD W (US)
Application Number:
PCT/US2004/021747
Publication Date:
April 14, 2005
Filing Date:
July 08, 2004
Export Citation:
Assignee:
SCHERING CORP (US)
DRAPER RICHARD W (US)
DRAPER RICHARD W (US)
International Classes:
C07C67/343; (IPC1-7): C07C67/343; C07C69/738
Foreign References:
| US2824121A | 1958-02-18 | |||
| US4851566A | 1989-07-25 |
Other References:
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002312395, Database accession no. 4087690
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