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Patent Searching and Data


Title:
PROCESS FOR PREPARATION OF PYRAZINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2011/126045
Kind Code:
A1
Abstract:
Provided is a process for the preparation of optically active 2,3-bisphosphinopyrazine derivatives, which is industrially advantageous and by which any isomer can be easily prepared. Specifically provided is a process for the preparation of optically active 2,3-bisphosphinopyrazine derivatives represented by general formula (A), which comprises the following steps (I), (II) and (III). In the formulae, R1 and R2 are a pair of groups that develops asymmetry on the phosphorus atom or that makes the phosphorus atom one point on an asymmetric plane, and are each hydrogen, a hydrocarbon group, or a substituted hydrocarbon group; R3 is an asymmetric hydrocarbon group or a substituted asymmetric hydrocarbon group; R4 and R5 are each hydrogen or alkyl, or alternatively R4 and R5 may be united to form a saturated or unsaturated ring; and X is a halogen atom.

Inventors:
MAYAMA DAISUKE (JP)
Application Number:
JP2011/058701
Publication Date:
October 13, 2011
Filing Date:
April 06, 2011
Export Citation:
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Assignee:
NIPPON CHEMICAL IND (JP)
MAYAMA DAISUKE (JP)
International Classes:
C07F9/6509; C07B53/00; C07F9/50; C07F5/02; C07F19/00
Foreign References:
JP2007056007A2007-03-08
JP2003300988A2003-10-21
JP2010138136A2010-06-24
Other References:
IMAMOTO, T. ET AL.: "Improved synthetic routes to methylene-bridged P-chiral diphosphine ligands via secondary phosphine-boranes", TETRAHEDRON: ASYMMETRY, vol. 21, no. 11-12, 2010, pages 1522 - 1528, XP027185373
Attorney, Agent or Firm:
NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP)
Nippon Chemical Industrial Co., Ltd. (JP)
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Claims: