Title:
PROCESS FOR PREPARATION OF PYRIMIDINYLPYRAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/086955
Kind Code:
A1
Abstract:
A process for the preparation of pyrimidinylpyrazole compounds (1), characterized by reacting aminoguanidine (2) or a salt thereof with a β-diketone compound (3). This process ensures excellent environmental compatibility and economic efficiency. In formulae (1) to (3), R1 and R3 are each independently C1-4 alkyl; and R2 is a hydrogen atom or C1-4 alkyl.
Inventors:
FUKUNISHI HIROTADA (JP)
HANYU NAOTO (JP)
SUETSUGU MASARU (JP)
HIRUMA TAKUYA (JP)
HANYU NAOTO (JP)
SUETSUGU MASARU (JP)
HIRUMA TAKUYA (JP)
Application Number:
PCT/JP2011/050045
Publication Date:
July 21, 2011
Filing Date:
January 05, 2011
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
FUKUNISHI HIROTADA (JP)
HANYU NAOTO (JP)
SUETSUGU MASARU (JP)
HIRUMA TAKUYA (JP)
FUKUNISHI HIROTADA (JP)
HANYU NAOTO (JP)
SUETSUGU MASARU (JP)
HIRUMA TAKUYA (JP)
International Classes:
C07D403/04
Domestic Patent References:
| WO2006100212A1 | 2006-09-28 | |||
| WO2009099192A1 | 2009-08-13 | |||
| WO2006100212A1 | 2006-09-28 | |||
| WO2009099192A1 | 2009-08-13 |
Foreign References:
| JPS62404A | 1987-01-06 | |||
| JP2003313450A | 2003-11-06 | |||
| US3865825A | 1975-02-11 | |||
| JPS54117029A | 1979-09-11 | |||
| JPS54147921A | 1979-11-19 | |||
| JPS62404A | 1987-01-06 | |||
| JPS4219593B1 |
Other References:
KAZUO KONISHI ET AL.: "Fungicidal Activity of Pyrazolylpyrimidines", JOURNAL OF PESTICIDE SCIENCE, vol. 15, no. 1, 1990, pages 13 - 22, XP008060627
RANJEET BAIRWA ET AL.: "Novel Regiospecific Method for Synthesis of 2-(3,5-Diaryl-4,5- dihydro-lH-pyrazol-1-yl)-4,6-diarylpyrimid ines", SYNTHETIC COMMUNICATIONS, vol. 38, 2008, pages 943 - 952
HELIO GAUZE BONACORSO ET AL.: "Regiospecific Cyclization of -Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2-[1H- Pyrazol-1-yl]pyrimidines", SYNTHESIS, no. 10, 2001, pages 1505 - 1508
SYNTHESIS, vol. 10, 2001, pages 1505 - 1508
BOLLETTINO CHIMICO FARMACEUTICO, vol. 137, no. 4, 1998, pages 110 - 114
See also references of EP 2527341A4
RANJEET BAIRWA ET AL.: "Novel Regiospecific Method for Synthesis of 2-(3,5-Diaryl-4,5- dihydro-lH-pyrazol-1-yl)-4,6-diarylpyrimid ines", SYNTHETIC COMMUNICATIONS, vol. 38, 2008, pages 943 - 952
HELIO GAUZE BONACORSO ET AL.: "Regiospecific Cyclization of -Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2-[1H- Pyrazol-1-yl]pyrimidines", SYNTHESIS, no. 10, 2001, pages 1505 - 1508
SYNTHESIS, vol. 10, 2001, pages 1505 - 1508
BOLLETTINO CHIMICO FARMACEUTICO, vol. 137, no. 4, 1998, pages 110 - 114
See also references of EP 2527341A4
Attorney, Agent or Firm:
IWAHASHI YUJI (JP)
Yuji Iwahashi (JP)
Yuji Iwahashi (JP)
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Claims: