Title:
PROCESS FOR PREPARATION OF STATINS WITH HIGH SYN TO ANTI RATIO
Document Type and Number:
WIPO Patent Application WO2005063728
Kind Code:
A3
Abstract:
Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.
Inventors:
LIFSHITZ-LIRON REVITAL (IL)
PERLMAN NURIT (IL)
PERLMAN NURIT (IL)
Application Number:
PCT/US2004/043466
Publication Date:
February 23, 2006
Filing Date:
December 23, 2004
Export Citation:
Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
LIFSHITZ-LIRON REVITAL (IL)
PERLMAN NURIT (IL)
TEVA PHARMA (US)
LIFSHITZ-LIRON REVITAL (IL)
PERLMAN NURIT (IL)
International Classes:
C07C69/66; C07D309/00; (IPC1-7): C07D309/00
Foreign References:
| US5354772A | 1994-10-11 |
Other References:
J. ORG. CHEM., 1990, pages 5190-5192, XP002334937
TEMPKIN O ET AL: "Asymmetric Synthesis of 3,5-Dihydroxy-6(E)-heptenoate-containing HMG-CoA Reductase Inhibitors", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 31, 4 August 1997 (1997-08-04), pages 10659 - 10670, XP004105948, ISSN: 0040-4020
TEMPKIN O ET AL: "Asymmetric Synthesis of 3,5-Dihydroxy-6(E)-heptenoate-containing HMG-CoA Reductase Inhibitors", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 31, 4 August 1997 (1997-08-04), pages 10659 - 10670, XP004105948, ISSN: 0040-4020
Download PDF: