Title:
PROCESS FOR THE PREPARATION OF SUNITINIB MALATE FORM I
Document Type and Number:
WIPO Patent Application WO/2011/104555
Kind Code:
A3
Abstract:
The present invention relates to an improved process for preparing acid addition salts of sunitinib, in particular sunitinib (2S)-2-hydroxybutanedioate (I). The invention also relates to compositions comprising sunitinib acid addition salts such as sunitinib (2S)-2- hydroxybutanedioate (I) and to the use of said compositions in the treatment of disease.
Inventors:
GORE VINAYAK GOVIND (IN)
PATKAR LAXMIKANT NARAHARI (IN)
POKHARKAR KIRAN SHIVAJI (IN)
HUBLIKAR MAHESH GORAKHNATH (IN)
BANSODE PRAKASH VISHNU (IN)
PATKAR LAXMIKANT NARAHARI (IN)
POKHARKAR KIRAN SHIVAJI (IN)
HUBLIKAR MAHESH GORAKHNATH (IN)
BANSODE PRAKASH VISHNU (IN)
Application Number:
PCT/GB2011/050369
Publication Date:
February 02, 2012
Filing Date:
February 24, 2011
Export Citation:
Assignee:
GENERICS UK LTD (GB)
MYLAN INDIA PRIVATE LTD (IN)
GORE VINAYAK GOVIND (IN)
PATKAR LAXMIKANT NARAHARI (IN)
POKHARKAR KIRAN SHIVAJI (IN)
HUBLIKAR MAHESH GORAKHNATH (IN)
BANSODE PRAKASH VISHNU (IN)
MYLAN INDIA PRIVATE LTD (IN)
GORE VINAYAK GOVIND (IN)
PATKAR LAXMIKANT NARAHARI (IN)
POKHARKAR KIRAN SHIVAJI (IN)
HUBLIKAR MAHESH GORAKHNATH (IN)
BANSODE PRAKASH VISHNU (IN)
International Classes:
C07D403/06; A61K31/404
Domestic Patent References:
| WO2001060814A2 | 2001-08-23 | |||
| WO2009150523A1 | 2009-12-17 | |||
| WO2009157011A1 | 2009-12-30 |
Other References:
J. H. VAN 'T HOFF, H. M. DAWSON: "Die racemische Umwandlung des Ammoniumbimalats", CHEMISCHE BERICHTE, vol. 31, no. 1, 1898, pages 528 - 534, XP002630290
KAY SCHWARZKOPF ET AL: "Synthesis of Novel Optically Active Tin Hydrides Containing Chiral Ligands", CHEMISCHE BERICHTE, vol. 130, 1997, pages 1539 - 1546, XP002630291
TADASHI SHIRAIWA ET AL: "Racemic Structure and Optical Resolution by Preferential Crystalization of (+/-)-Organic Ammonium Hydrogen Malates", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, 1988, pages 899 - 903, XP002630292
KAY SCHWARZKOPF ET AL: "Synthesis of Novel Optically Active Tin Hydrides Containing Chiral Ligands", CHEMISCHE BERICHTE, vol. 130, 1997, pages 1539 - 1546, XP002630291
TADASHI SHIRAIWA ET AL: "Racemic Structure and Optical Resolution by Preferential Crystalization of (+/-)-Organic Ammonium Hydrogen Malates", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, 1988, pages 899 - 903, XP002630292
Attorney, Agent or Firm:
ELEND, Almut et al. (Byron HouseCambridge Business Park,Cowley Road, Cambridge Cambridgeshire CB4 0WZ, GB)
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