Title:
PROCESS FOR THE PREPARATION OF TELMISARTAN
Document Type and Number:
WIPO Patent Application WO/2010/146187
Kind Code:
A3
Abstract:
The invention relates to processes for preparing telmisartan or a pharmaceutically acceptable salt thereof as well as to a process for preparing a telmisartan cyano intermediate. Moreover, the invention relates to a multilayer pharmaceutical tablet comprising (a) at least one first tablet layer comprising 1 to 50 wt. -% telmisartan or a pharmaceutically acceptable salt thereof by weight of the first tablet layer and (b) at least one second tablet layer comprising 1 to 50 wt.-% of a diuretic and 50 to 99 wt.-% of at least one filler by weight of the second tablet layer, wherein the combined weight of the diuretic and the at least one filler is at least 87 wt.-% by weight of the second tablet layer. The invention also relates to a process for the preparation of a multilayer pharmaceutical tablet.
Inventors:
ZUPANCIC SILVO (SI)
SEDMAK GREGOR (SI)
SEDMAK GREGOR (SI)
Application Number:
PCT/EP2010/058754
Publication Date:
February 24, 2011
Filing Date:
June 21, 2010
Export Citation:
Assignee:
KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI)
ZUPANCIC SILVO (SI)
SEDMAK GREGOR (SI)
ZUPANCIC SILVO (SI)
SEDMAK GREGOR (SI)
International Classes:
C07D235/20; A61K31/4184; A61P9/12
Domestic Patent References:
| WO2007147889A2 | 2007-12-27 | |||
| WO2004087676A1 | 2004-10-14 | |||
| WO2005108375A1 | 2005-11-17 |
Foreign References:
| US20060264491A1 | 2006-11-23 |
Other References:
GUO X Z ET AL: "Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB LNKD- DOI:10.1016/J.BMC.2008.10.040, vol. 16, no. 24, 15 December 2008 (2008-12-15), pages 10301 - 10310, XP025685121, ISSN: 0968-0896, [retrieved on 20081022]
Attorney, Agent or Firm:
UEXKÜLL & STOLBERG (Hamburg, DE)
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