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Patent Searching and Data


Title:
A PROCESS FOR THE PREPARATION OF TREOSULFAN
Document Type and Number:
WIPO Patent Application WO/2019/043587
Kind Code:
A3
Abstract:
The present invention relates to a process for the preparation of Treosulfan using sodium borohydride and iodine as reducing agent, which is less hazardous and convenient as compared to the reagents used in the prior art. The invention also relates to a novel intermediate to obtain Treosulfan in high yield and high purity.

Inventors:
SHARMA ASHWANI KUMAR (IN)
UPADHYAY SAURABH (IN)
DUA HEENA (IN)
MUSMADE SACHIN (IN)
SINGH GOVIND (IN)
LAHIRI SASWATA (IN)
CABRI WALTER (IT)
Application Number:
PCT/IB2018/056573
Publication Date:
June 27, 2019
Filing Date:
August 29, 2018
Export Citation:
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Assignee:
FRESENIUS KABI ONCOLOGY LTD (IN)
International Classes:
C07C309/68; A61P35/00; C07D317/18; C07D317/32
Foreign References:
US3246012A1966-04-12
IN1568MU2012A2014-01-17
Other References:
PONMINOR SENTHIL KUMAR ET AL: "Truly Catalytic and Chemoselective Cleavage of Benzylidene Acetal with Phosphomolybdic Acid Supported on Silica Gel", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2008, no. 36, December 2008 (2008-12-01), DE, pages 6063 - 6067, XP055532116, ISSN: 1434-193X, DOI: 10.1002/ejoc.200800963
FRANCOISE BARRIER-E ET AL: "NOVEL (4 + 1) FRAGMENT COMBINATION APPROACH TO CHIRAL CYCLOPENTANOIDS FROhl TARTARIC ACID", TETRAHEDRON LETTERSOO PRINTED IN GREAT BRITAIN, 1985, pages 3121 - 3124, XP055532039, Retrieved from the Internet [retrieved on 20181212]
RADOSLAV CHEKEROV ET AL: "Treosulfan in the Treatment of Advanced Ovarian Cancer - Results of a German Multicenter Non-interventional Study", ANTICANCER RESEARCH, December 2015 (2015-12-01), pages 6869 - 6876, XP055533170, Retrieved from the Internet [retrieved on 20181212]
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