Title:
PROCESS FOR THE PREPARATION OF VORTIOXETINE SALTS
Document Type and Number:
WIPO Patent Application WO/2015/114395
Kind Code:
A9
Abstract:
The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature l-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L- (+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.
Inventors:
LING ISTVÁN (HU)
JEGES GYÖRGY (HU)
KOVÁNYNÉ LAX GYÖRGYI (HU)
VOLK BALÁZS (HU)
GREGOR PÉTER (HU)
SERES JENŐ PÉTER (HU)
DANCSÓ ANDRÁS (HU)
VARGA ZOLTÁN (HU)
SZABÓ ÉVA (HU)
JEGES GYÖRGY (HU)
KOVÁNYNÉ LAX GYÖRGYI (HU)
VOLK BALÁZS (HU)
GREGOR PÉTER (HU)
SERES JENŐ PÉTER (HU)
DANCSÓ ANDRÁS (HU)
VARGA ZOLTÁN (HU)
SZABÓ ÉVA (HU)
Application Number:
PCT/HU2015/000007
Publication Date:
December 03, 2015
Filing Date:
January 30, 2015
Export Citation:
Assignee:
EGIS GYÓGYSZERGYÁR ZRT (HU)
International Classes:
C07D295/08; A61K31/495; A61P25/28
Attorney, Agent or Firm:
KOVÁRI, Zoltán (Attila út 125, 1012 Budapest, HU)
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