Title:
PROCESS FOR PREPARING 2-(2-HYDROXYPHENYL)-BENZ[1,3]OXAZIN-4-ONE AND ITS USE FOR PREPARING DEFERASIROX
Document Type and Number:
WIPO Patent Application WO/2012/025935
Kind Code:
A3
Abstract:
Disclosed is a process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising reacting salicylic acid with p-toluenesulfonyl chloride in the presence of a base and an organic solvent, and then combining the obtained tosylated compound with salicylamide. The use of2-(2-hydroxyphenyl)-benz[13]oxazin-4-one in the preparation of Deferasirox is also disclosed.
Inventors:
DAVULURI RAMAMOHAN RAO (IN)
PONNAIAH RAVI (IN)
BATTHNI GURUSWAMY (IN)
MEDIDA CHANDRA MURTHY V R (IN)
DUMMU SANTHOSH (IN)
PONNAIAH RAVI (IN)
BATTHNI GURUSWAMY (IN)
MEDIDA CHANDRA MURTHY V R (IN)
DUMMU SANTHOSH (IN)
Application Number:
PCT/IN2011/000560
Publication Date:
April 19, 2012
Filing Date:
August 23, 2011
Export Citation:
Assignee:
DAVULURI RAMAMOHAN RAO (IN)
International Classes:
C07D265/22
Domestic Patent References:
| WO2009130604A2 | 2009-10-29 | |||
| WO2010023685A2 | 2010-03-04 |
Other References:
SUN, MIN ET AL.: "Synthesis of deferasirox, an iron chelator", CHINESE JOURNAL OF NEW DRUGS, vol. 18, no. 9, 2009, pages 850 - 851, XP008169335
STEINHAUSER S. ET AL.: "Complex Formation of ICL670 and Related Ligands with FeIII and FeII", EUR. J. INORG. CHEM., vol. 2004, no. 21, 13 September 2004 (2004-09-13), pages 4177 - 4192, XP002484059
See also references of EP 2632907A4
STEINHAUSER S. ET AL.: "Complex Formation of ICL670 and Related Ligands with FeIII and FeII", EUR. J. INORG. CHEM., vol. 2004, no. 21, 13 September 2004 (2004-09-13), pages 4177 - 4192, XP002484059
See also references of EP 2632907A4
Attorney, Agent or Firm:
NATARAJAN, Ramaswami (Swagat ApartmentsThiruvalluvar Nagar, Thiruvanmiyur,Chennai 1, Tamil Nadu, IN)
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