Title:
PROCESS FOR PREPARING (2R,3S)-3-(SUBSTITUTED OR UNSUBSTITUTED PHENYL)GLYCIDAMIDE COMPOUNDS BY ASYMMETRIC AMIDATION
Document Type and Number:
WIPO Patent Application WO/1999/007875
Kind Code:
A1
Abstract:
A novel process for preparing (2R,3S)-3-(substituted or unsubstituted phenyl)glycidamide compounds, characterized by reacting a racemic trans-3-(substituted or unsubstituted phenyl)glycidic ester compound with ammonia or an amine compound in the presence of an enzyme having a capability of asymmetrically amidating glycidic ester compounds to amidate the (2R,3S)-isomer, and separating and harvesting the resultant (2R,3S)-amide compound from the reaction solution; and a process for preparing (2R,3S)-1,5-benzothiazepine derivatives useful as a pharmaceutical, by reacting the (2R,3S)-glycidamide compound prepared above with a 2-aminothiophenol derivative and subjecting the product to ring closure.
Inventors:
TSUJIOKA IKUKO (JP)
MATSUMAE HIROAKI (JP)
NISHIDA TAKUO (JP)
SHIBATANI TAKEJI (JP)
MATSUMAE HIROAKI (JP)
NISHIDA TAKUO (JP)
SHIBATANI TAKEJI (JP)
Application Number:
PCT/JP1998/003453
Publication Date:
February 18, 1999
Filing Date:
August 04, 1998
Export Citation:
Assignee:
TANABE SEIYAKU CO (JP)
TSUJIOKA IKUKO (JP)
MATSUMAE HIROAKI (JP)
NISHIDA TAKUO (JP)
SHIBATANI TAKEJI (JP)
TSUJIOKA IKUKO (JP)
MATSUMAE HIROAKI (JP)
NISHIDA TAKUO (JP)
SHIBATANI TAKEJI (JP)
International Classes:
C07D281/10; C07D303/48; C12P17/02; C12P41/00; (IPC1-7): C12P41/00; C07D281/10
Domestic Patent References:
| WO1995007359A1 | 1995-03-16 |
Foreign References:
| JPS6013776A | 1985-01-24 |
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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