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Title:
PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2010/094674
Kind Code:
A3
Abstract:
A process for preparing N-[(1lR)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)- phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

Inventors:
CATOZZI, Nicola (Via 4 Novembre 111, Sovizzo, I-36050, IT)
COTARCA, Livius (Via Mercato 18, Cervignano del Friuli, I-33052, IT)
FOLETTO, Johnny (Via Molinazzo, 34/a, Arcole, I-37040, IT)
FORCATO, Massimiliano (Via Porto 25/B, Galzignano Terme, I-35030, IT)
GIOVANETTI, Roberto (Via L. da Vinci, 121, Schio, I-36015, IT)
SORIATO, Giorgio (Via delle Terme 22, Caldiero, I-37042, IT)
VERZINI, Massimo (Via Terme 10, Caldiero, I-37042, IT)
Application Number:
EP2010/051900
Publication Date:
October 21, 2010
Filing Date:
February 16, 2010
Export Citation:
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Assignee:
ZACH SYSTEM S.P.A. (Via Lillo del Duca 10, Bresso, I-20091, IT)
CATOZZI, Nicola (Via 4 Novembre 111, Sovizzo, I-36050, IT)
COTARCA, Livius (Via Mercato 18, Cervignano del Friuli, I-33052, IT)
FOLETTO, Johnny (Via Molinazzo, 34/a, Arcole, I-37040, IT)
FORCATO, Massimiliano (Via Porto 25/B, Galzignano Terme, I-35030, IT)
GIOVANETTI, Roberto (Via L. da Vinci, 121, Schio, I-36015, IT)
SORIATO, Giorgio (Via delle Terme 22, Caldiero, I-37042, IT)
VERZINI, Massimo (Via Terme 10, Caldiero, I-37042, IT)
International Classes:
C07C209/68; C07C209/70; C07C211/62; C07C221/00; C07C303/24; C07C305/18
Domestic Patent References:
WO2007127449A12007-11-08
WO2009002427A22008-12-31
WO2009153814A12009-12-23
WO2010015935A22010-02-11
WO2010049293A22010-05-06
Other References:
STUETZ A ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NAFTIFINE-RELATED ALLYLAMINE ANTIMYCOTICS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM00151A019, vol. 29, no. 1, 1 January 1986 (1986-01-01), pages 112 - 125, XP002037080, ISSN: 0022-2623
THIEL ET AL: "Practical synthesis of the calcimimetic agent, cinacalcet", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TETLET.2007.11.030, vol. 49, no. 1, 26 November 2007 (2007-11-26), pages 13 - 15, XP022374243, ISSN: 0040-4039
Attorney, Agent or Firm:
ZACH SYSTEM S.P.A. (Intellectual Property Dept, Via Lillo del Duca 10, Bresso, I-20091, IT)
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