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Patent Searching and Data


Title:
PROCESS FOR PREPARING CLOPIDOGREL
Document Type and Number:
WIPO Patent Application WO2002059128
Kind Code:
A3
Abstract:
The present invention discloses a process for the preparation of thieno[3,2-c]pyridine derivatives of general formula (I), in either racemic or optically active (+) or (-) forms and their salts, wherein X, the substituent on benzene ring represents either a hydrogen or halogen atom such as fluorine, chlorine, bromine or iodine. The present invention also describes a process for preparing the compounds of general formula (II), in either racemic or optically active (+) or (-) forms and their salts, where X, the substituent on benzene ring represents either a hydrogen or halogen atom such as fluorine, chlorine, bromine or iodine. The compounds represented by formulae (I) and (II) have one asymmetric carbon and hence, the optically active compounds of formula (I) or of formula (ii), may be obtained either by resolving the racemic intermediate/final product or using an optically active intermediate. The compounds of the invention are pharmacologically active and have significant anti-aggregating and anti-thrombotic properties.

Inventors:
PANDEY BIPIN (IN)
LOHRAY VIDYA BHUSHAN (IN)
LOHRAY BRAJ BHUSHAN (IN)
Application Number:
IN0200012W
Publication Date:
December 19, 2002
Filing Date:
January 21, 2002
Export Citation:
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Assignee:
CADILA HEALTHCARE LTD.
PANDEY, BIPIN
LOHRAY, VIDYA, BHUSHAN
LOHRAY, BRAJ, BHUSHAN
International Classes:
A61K31/4365; A61P7/02; C07B55/00; C07B57/00; C07D495/04; (IPC1-7): C07D495/04
Foreign References:
US4529596A1985-07-16
Other References:
ALAIN BURGOS, JOHN M. HERBERT AND IAIN SIMPSON: 'ortho-Metalaton/Chlorination of Benzoic Acid Derivatives. Preparation of [benzene-U-13C]-rac-Clopidogrel ([benzene-U-13C]-rac-SR25990C)' J. LABELLED COMPD. RADIOPHARM. vol. 43, no. 9, 2000, pages 891 - 8, XP008008850
JERRY MARCH: "Advanced Organic Chemistry" 1992 , WILEY & SONS , NEW YORK XP002215119 198280 The HCN can be generated in situ from acetone cyanohydrin (see 6-49), avoiding the use of poisonous HCN. page 812 The addition of HCN ... This is an equilibrium reaction. page 964 Frequently it is the bisulfite addition product that is treated with CN- page 965 6-51 The addition of HCN to C=N and CN Bonds page 966
NAJER ET AL.: "Nitriles, amides, thioamides et acides alpha-phenyle alpha-tertioaminoacötiques" BULL. SOC. CHIM. FR., 1958, pages 1189-92, XP002215118
See also references of EP 1353928A2
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