PROCESS FOR PREPARING ERIANIN - ZHE JIANG CELL BIOMEDICAL RES

Title:

PROCESS FOR PREPARING ERIANIN

Document Type and Number:

WIPO Patent Application WO/2007/006230

Kind Code:

A1

Abstract:

The present invention relates to a process for preparing Erianin (Dihydro Combretastatin A-4), whererin 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) having a protected hydroxy in the 3-position, followed by hydrogenation and deprotection.

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Inventors:

LI YIPING (CN)
LIU SHUANGXI (CN)

Application Number:

PCT/CN2006/001649

Publication Date:

January 18, 2007

Filing Date:

July 12, 2006

Export Citation:

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Assignee:

ZHE JIANG CELL BIOMEDICAL RES (CN)
LI YIPING (CN)
LIU SHUANGXI (CN)

International Classes:

C07C41/20; A61P35/00; C07C43/253

Foreign References:

US5430062A	1995-07-04
CN1660745A	2005-08-31
CN1704393A	2005-12-07
US6759555B2	2004-07-06

Other References:

GETAHUN Z. ET AL.: "Synthesis of Alkoxy-Substituted Diaryl Compounds and Correlation of Ring Separation with Inhibition of Tubulin Polymerization Differential Enhancement of Inhibitory Effects under Suboptimal Polymerization Reaction Conditions", J. MED. CHEM., vol. 35, no. 6, 1992, pages 1058 - 1067, XP002906721

Attorney, Agent or Firm:

LECOME INTELLECTUAL PROPERTY AGENT LTD. (Quantum Silver Plaza No.23 Zhichun Rd. Haidian District, Beijing3, CN)

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