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Patent Searching and Data


Title:
PROCESS FOR PREPARING ERIANIN
Document Type and Number:
WIPO Patent Application WO/2007/006230
Kind Code:
A1
Abstract:
The present invention relates to a process for preparing Erianin (Dihydro Combretastatin A-4), whererin 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) having a protected hydroxy in the 3-position, followed by hydrogenation and deprotection.

Inventors:
LI YIPING (CN)
LIU SHUANGXI (CN)
Application Number:
CN2006/001649
Publication Date:
January 18, 2007
Filing Date:
July 12, 2006
Export Citation:
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Assignee:
ZHE JIANG CELL BIOMEDICAL RES (CN)
LI YIPING (CN)
LIU SHUANGXI (CN)
International Classes:
C07C41/20; A61P35/00; C07C43/253
Foreign References:
US5430062A1995-07-04
CN1660745A2005-08-31
CN1704393A2005-12-07
US6759555B22004-07-06
Other References:
GETAHUN Z. ET AL.: "Synthesis of Alkoxy-Substituted Diaryl Compounds and Correlation of Ring Separation with Inhibition of Tubulin Polymerization Differential Enhancement of Inhibitory Effects under Suboptimal Polymerization Reaction Conditions", J. MED. CHEM., vol. 35, no. 6, 1992, pages 1058 - 1067, XP002906721
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (Quantum Silver Plaza No.23 Zhichun Rd. Haidian District, Beijing3, CN)
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