Title:
PROCESS FOR PREPARING ESTRONE ACETAL
Document Type and Number:
WIPO Patent Application WO/1984/003094
Kind Code:
A1
Abstract:
In a process for reacting sodium with a polycyclic aromatic compound in a reaction solvent to prepare a radical anion, and introducing androsta-1,4-diene-3,17-dione-17-acetal into the obtained reaction mixture to reduce it to estrone acetal, the improvement which comprises using as a reaction solvent one comprising a polyether having 3 or more ether bonds with its concentration maintained above a predetermined value and conducting the reaction at temperatures not lower than the melting point of sodium and not higher than 105oC. This process enables estrone acetal to be prepared on an industrial scale in high yields and with economical advantages. The resulting estrone acetal is useful as a precursor for estrone important as female sex hormone.
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Inventors:
KINUGASA KAZUMASA (JP)
TANAKA EIICHIRO (JP)
TANAKA YOSHIHIRO (JP)
MORITA YOSHIHARU (JP)
TANAKA EIICHIRO (JP)
TANAKA YOSHIHIRO (JP)
MORITA YOSHIHARU (JP)
Application Number:
PCT/JP1984/000030
Publication Date:
August 16, 1984
Filing Date:
February 01, 1984
Export Citation:
Assignee:
MITSUBISHI CHEM IND (JP)
International Classes:
C07J1/00; C07J21/00; (IPC1-7): C07J1/00; C07J21/00
Foreign References:
| JPS5549398A | 1980-04-09 | |||
| JPS5551099A | 1980-04-14 |
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