Title:
PROCESS FOR PREPARING INTERFERON DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1985/005618
Kind Code:
A1
Abstract:
A novel polypeptide having an activity equal or superior to that of IFN-gamma and difficultly undergoing dimerization or polymerization, a transforment containing DNA which codes the novel polypeptide, and a process for preparing the novel polypeptide from a culture product of the transformant. DNA coding the novel polypeptide can be prepared from known IFN-gamma gene (cDNA)-containing plasmid, PHITtrp1101. This DNA is bound to a vector and introduced into a host to give a transformant. An antibody column is used for purifying the polypeptide from the culture product. The novel polypeptide can be used as antiviral and antineoplastic agents.
Inventors:
KIKUCHI MASAKAZU (JP)
KUROKAWA TSUTOMU (JP)
HONDA SUSUMU (JP)
KUROKAWA TSUTOMU (JP)
HONDA SUSUMU (JP)
Application Number:
PCT/JP1984/000292
Publication Date:
December 19, 1985
Filing Date:
June 06, 1984
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
International Classes:
C12N15/09; A61K38/21; C07H21/04; C07K1/22; C07K14/00; C07K14/52; C07K14/555; C07K14/57; C12N1/20; C12P21/02; A61K38/00; C12R1/19; (IPC1-7): C07C103/52; A61K45/02; C12N1/20; C12P21/02
Foreign References:
| JPS5951792A | 1984-03-26 | |||
| JPS5890514A | 1983-05-30 |
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