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Title:
PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/072237
Kind Code:
A1
Abstract:
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound (f), which comprises conducting a cyclization reaction of compound (e) in a solvent and in the presence of a base to give compound (f). The process of the present invention does not involve the steps of catalytic reduction or catalytic coupling reaction of precious metals and chiral separation, which has advantages such as low equipment requirements, simple operation, favorable industrial production, avoiding waste liquid containing heavy metals and phosphorus, low cost and high product ee value.

Inventors:
WANG, Tianhao (4560 Jinke Rd, Bldg. 1 4/F, Pilot Free Trade Zone, Shanghai 0, 201210, CN)
Application Number:
CN2018/110025
Publication Date:
April 18, 2019
Filing Date:
October 12, 2018
Export Citation:
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Assignee:
ZAI LAB (SHANGHAI) CO., LTD. (4560 Jinke Rd, Bldg. 1 4/F, Pilot Free Trade Zone, Shanghai 0, 201210, CN)
International Classes:
C07D211/76; A61K31/16; A61K31/416; C07B57/00; C07D211/02
Foreign References:
CN106854176A2017-06-16
CN106432056A2017-02-22
Other References:
MERCEDES AMAT ET AL.: "Dynamic Kinetic Resolution of Racemic 7-Aryl-b-oxoesters. Enantioselective Synthesis of 3-Arylpiperidines", J. ORG. CHEM., 26 June 2002 (2002-06-26), pages 5343 - 5351, XP055592156
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor SFECO Mansion 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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