Title:
PROCESS OF PREPARING NUCLEIC ACID OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2021/153770
Kind Code:
A1
Abstract:
The present invention provides an efficient process for preparing a nucleic acid oligomer, that is, a process for preparing a nucleic acid having a phosphate triester bond effectively by oxidizing a nucleic acid precursor having a phosphite triester bond. Specifically, the present invention provides a process for preparing a nucleic acid compound having at its 5'-terminus a nucleotide represented by formula (I) by a phosphoramidite method, which comprises a step of reacting a precursor having a phosphite triester bond represented by a formula (II) (the definitions of substituents of formulae (I) and (II) are described in the Description) with an oxidation solution subjected to a heat-treatment that contains iodine, pyridine and water.
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Inventors:
MIYAGAWA TAKUYA (JP)
Application Number:
PCT/JP2021/003351
Publication Date:
August 05, 2021
Filing Date:
January 29, 2021
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07H1/00; C07H21/02; C07K5/062
Domestic Patent References:
| WO2018212236A1 | 2018-11-22 | |||
| WO2013027843A1 | 2013-02-28 | |||
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Other References:
TETRAHEDRON, vol. 69, 2013, pages 3615 - 3637
XIULONG, SHEN ET AL., NUCLEIC ACIDS RESEARCH, vol. 46, no. 46, 2018, pages 1584 - 1600
DANIEL O'REILLY ET AL., NUCLEIC ACIDS RESEARCH, vol. 47, no. 2, 2019, pages 547 - 558
XIULONG, SHEN ET AL., NUCLEIC ACIDS RESEARCH, vol. 46, no. 46, 2018, pages 1584 - 1600
DANIEL O'REILLY ET AL., NUCLEIC ACIDS RESEARCH, vol. 47, no. 2, 2019, pages 547 - 558
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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