Title:
PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/089268
Kind Code:
A3
Abstract:
The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz [b,e] oxepin -1 1- one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate l l -[(Z)-3-(dimethylamino)-propylidene] -6- l l -dihvdrodibenz[b,e]-oxepin-2-acet- amide p-toluensulfonate salt.
Inventors:
GUIDI ALBERTO (IT)
CHIARELLO FILIPPO (IT)
ORRU GIANMAURO (IT)
VERZINI MASSIMO (IT)
COTARCA LIVIUS (IT)
KIZIRIAN JEAN-CLAUDE (FR)
TREPAT GUIXER ELISENDA (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
CHIARELLO FILIPPO (IT)
ORRU GIANMAURO (IT)
VERZINI MASSIMO (IT)
COTARCA LIVIUS (IT)
KIZIRIAN JEAN-CLAUDE (FR)
TREPAT GUIXER ELISENDA (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
Application Number:
PCT/EP2010/051148
Publication Date:
October 14, 2010
Filing Date:
February 01, 2010
Export Citation:
Assignee:
ZACH SYSTEM SPA (IT)
GUIDI ALBERTO (IT)
CHIARELLO FILIPPO (IT)
ORRU GIANMAURO (IT)
VERZINI MASSIMO (IT)
COTARCA LIVIUS (IT)
KIZIRIAN JEAN-CLAUDE (FR)
TREPAT GUIXER ELISENDA (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
GUIDI ALBERTO (IT)
CHIARELLO FILIPPO (IT)
ORRU GIANMAURO (IT)
VERZINI MASSIMO (IT)
COTARCA LIVIUS (IT)
KIZIRIAN JEAN-CLAUDE (FR)
TREPAT GUIXER ELISENDA (ES)
MARQUILLAS OLONDRIZ FRANCISCO (ES)
International Classes:
C07D313/12
Domestic Patent References:
| WO2007119120A2 | 2007-10-25 | |||
| WO2007110761A2 | 2007-10-04 |
Foreign References:
| US20050288283A1 | 2005-12-29 | |||
| EP0214779A1 | 1987-03-18 | |||
| EP0235796A2 | 1987-09-09 | |||
| US4282365A | 1981-08-04 |
Other References:
OHSHIMA E ET AL: "SYNTHESIS AND ANTIALLERGIC ACTIVITY OF 11-(AMINOALKYLIDENE)-6,11-DIHY DRODIBENZĂB,E 3/4 OXEPIN DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM00089A020, vol. 35, no. 11, 1 May 1992 (1992-05-01), pages 2074 - 2084, XP000615220, ISSN: 0022-2623
Attorney, Agent or Firm:
ZACH SYSTEM S.P.A. (Via Lillo del Duca 10, Bresso, IT)
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