PROCESS FOR PREPARING PACLITAXEL FROM 10-DEACETYLPACLITAXEL

Title:

PROCESS FOR PREPARING PACLITAXEL FROM 10-DEACETYLPACLITAXEL

Document Type and Number:

WIPO Patent Application WO/2013/048204

Kind Code:

A3

Abstract:

This disclosure relates to a process of preparing paclitaxel with high yield by semi-synthesis of paclitaxel from paclitaxel intermediate in one pot. According to the preparation process of the present invention, total steps may be progressed in one-pot reaction without separating intermediate by using 10-deacetylpaclitaxel as starting material, the process is very economical because less amount of reagents may be used, paclitaxel may be obtained with high yield amounting to 80~95% even when the process is applied for mass production by including crystallization and purification processes, thus obtaining paclitaxel more easily and efficiently, and the process is very advantageous when applied for industrial mass production of paclitaxel.

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Inventors:

LEE NA-YOUNG (KR)
CHO JIN SUK (KR)

Application Number:

PCT/KR2012/007951

Publication Date:

May 23, 2013

Filing Date:

September 28, 2012

Export Citation:

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Assignee:

SAMYANG GENEXBIO CORP (KR)

International Classes:

A61K31/337

Domestic Patent References:

WO2000073293A1

2000-12-07

Foreign References:

US6232477B1	2001-05-15
US7563914B2	2009-07-21
US20070027330A1	2007-02-01
US5856532A	1999-01-05
US6177573B1	2001-01-23

Attorney, Agent or Firm:

YOU ME PATENT AND LAW FIRM (649-10Yoksam-dong,Kangnam-Ku, Seoul 135-080, KR)

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