PROCESS FOR PREPARING PHOSPHATE COMPOUND BEARING ISOTOPE

WIPO Patent Application WO/2012/153704

A1

A process for easily preparing a phosphate compound bearing an isotope is provided. This process includes an oxidation step of oxidizing a trivalent-phosphorus compound with an oxidizing agent that contains an isotope to synthesize a pentavalent-phosphorus compound into which the isotope has been introduced. The process is preferably applied to the synthesis of nucleic acids such as DNA and RNA. The isotope is preferably a stable isotope. The oxidizing agent is preferably H2 18O, 34S-bearing 3H-1,2-benzodithiol-3-one-1,1-dioxide, or 10B-bearing diisopropylethylamine borane complex.

WO/2020/191252	TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION
JPH09183789	NEW SULFATED AND PHOSPHATED SUGAR DERIVATIVE, ITS PRODUCTION AND USE

HAMASAKI TOMOHIRO (JP)
OHGI TADAAKI (JP)

PCT/JP2012/061652

November 15, 2012

May 07, 2012

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BONAC CORP (JP)
HAMASAKI TOMOHIRO (JP)
OHGI TADAAKI (JP)

C07H1/02; C07H21/02; C07B59/00

US5003097A

1991-03-26

WOJCIECH J. STEC ET AL.: "Automated Solid-Phase Synthesis, Separation, and Stereochemistry of Phosphorothioate Analogues of Oligodeoxyribonucleotides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 106, no. 20, 1984, pages 6077 - 6079, XP002410447
ADRIAN P. HIGSON ET AL.: "Synthesis of an Oligothymidylate Containing Boranophosphate Linkages", TETRAHEDRON LETTERS, vol. 39, no. 23, 1998, pages 3899 - 3902, XP004118769
J. ORG. CHEM., vol. 73, no. 1, 4 January 2008 (2008-01-04), pages 309 - 311
See also references of EP 2722335A4

TSUJIMARU Koichiro et al. (JP)
Koichiro Tsujimaru (JP)

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