Title:
PROCESS FOR PREPARING RACEMIC AND ENANTIOMERIC 1-(PYRIDYL)-2-CYCLOHEXYLETHYLAMINE
Document Type and Number:
WIPO Patent Application WO1996033173
Kind Code:
A3
Abstract:
Racemic mixtures of 1-(S,R)-(2-pyridyl)-2-cyclohexylethylamine are separated into (+)-(S)-1-(2-pyridyl)-2-cyclohexylethylamine or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine by admixture with (+)- or (-)-3-bromocamphor-8-sulfonic acid. 1-(S)-(2-pyridyl)-2-cyclohexylethylamine is an intermediate in the preparation of leukotriene biosynthesis inhibitors.
Inventors:
GROZINGER KARL GEORG (US)
Application Number:
PCT/US1996/003296
Publication Date:
December 05, 1996
Filing Date:
March 18, 1996
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (US)
GROZINGER KARL GEORG (US)
GROZINGER KARL GEORG (US)
International Classes:
C07B57/00; C07C309/25; C07D213/38; C07D405/12; (IPC1-7): C07D213/38
Foreign References:
| US5296486A | 1994-03-22 |
Other References:
M. AIQIAO ET AL.: "Asymmetric Synthesis XV: Enantioselective Syntheses of (R) or (S)-alpha-substituted-(2-pyridyl)methylamines via chiral pinanone ketimine template", SYNTH. COMMUN., vol. 21, no. 21, 1991, pages 2207 - 2212, XP000576650
E. S. LAZER ET AL.: "Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action", J. MED. CHEM., vol. 37, no. 7, 1994, pages 913 - 923, XP000574923
W. YULIANG ET AL.: "Solid-liquid phase transfer catalytic synthesis VII: The synthesis of alpha-substituted-2-pyridylmethylamine via the alkylation of benzaldehyde imine", SYNTH. COMMUN., vol. 22, no. 2, 1992, pages 265 - 269, XP000576649
L. A. PAQUETTE: "Encyclopedia of Reagents for Organic Synthesis, Vol. 1", 1995, JOHN WILEY & SONS, NEW YORK, XP002008969
E. S. LAZER ET AL.: "Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action", J. MED. CHEM., vol. 37, no. 7, 1994, pages 913 - 923, XP000574923
W. YULIANG ET AL.: "Solid-liquid phase transfer catalytic synthesis VII: The synthesis of alpha-substituted-2-pyridylmethylamine via the alkylation of benzaldehyde imine", SYNTH. COMMUN., vol. 22, no. 2, 1992, pages 265 - 269, XP000576649
L. A. PAQUETTE: "Encyclopedia of Reagents for Organic Synthesis, Vol. 1", 1995, JOHN WILEY & SONS, NEW YORK, XP002008969
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