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Title:
PROCESS FOR PROCUDING (2R,3S)-3-(4-METHOXYPHENYL)GLYDIDIC ACID ETHYL ESTER BY ENANTIOSELECTIVE HYDROLYSIS OF RACEMIC 3(4-METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER EMPLOYING LIPASE DERIVED FROM SERRATIA MARCESCENS AND/OR CANDIDA CYLINDRACEA
Document Type and Number:
WIPO Patent Application WO/2014/030106
Kind Code:
A3
Abstract:
The present invention relates to a process for producing an optically active (2S,3S)-3- hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one (Cis-lactam). More particularly, this invention relates to a process for making (2R,3S)-3-(4- methoxyphenyl)glycidic acid methyl ester employing enzymes, which is simple, industrially applicable and economically viable.

Inventors:
HUSAIN, Mofazzal (Fact 337, Kerala Nalsarovar Road,Vill.: Kerala, Tal.: Bavla, Dist.:, Ahmedabad 0, 382 22, IN)
CHAUHAN, Yogendra (Fact 337, Kerala Nalsarovar Road,Vill.: Kerala, Tal.: Bavla, Dist.:, Ahmedabad 0, 382 22, IN)
Application Number:
IB2013/056675
Publication Date:
February 27, 2014
Filing Date:
August 16, 2013
Export Citation:
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Assignee:
UNIMARK REMEDIES LTD. (Enterprise Centre, 1st FloorOff. Nehru Road,,Near Hotel Orchid,Vile Parle, Mumbai 9, 400 09, IN)
International Classes:
C12P7/40; C07C59/64; C07D281/10; C07D303/02; C12P7/62; C12P17/02; C12P17/14; C12P41/00
Domestic Patent References:
1990-05-03
Other References:
WANG, Y. ET AL.: "Significantly Improved Expression and Biochemical Properties of Recombinant Serratia marcescens Lipase as Robust Biocatalyst for Kinetic Resolution of Chiral Ester", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 162, no. 8, December 2010 (2010-12), pages 2387-2399, XP002720358,
ZHAO, L.L. ET AL.: "Biochemical properties and potential applications of an organic solvent-tolerant lipase isolated from Serratia marcescens ECU1010", PROCESS BIOCHEMISTRY, vol. 43, no. 6, June 2008 (2008-06), pages 626-633, XP022637311,
Attorney, Agent or Firm:
NAIR, Manisha Singh (Intellectual Property Practice, 709/710 Tolstoy House,15 - 17, Tolstoy Marg, New Delhi 1, 11000, IN)
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