Title:
PROCESS FOR PROCUDING (2R,3S)-3-(4-METHOXYPHENYL)GLYDIDIC ACID ETHYL ESTER BY ENANTIOSELECTIVE HYDROLYSIS OF RACEMIC 3(4-METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER EMPLOYING LIPASE DERIVED FROM SERRATIA MARCESCENS AND/OR CANDIDA CYLINDRACEA
Document Type and Number:
WIPO Patent Application WO/2014/030106
Kind Code:
A3
Abstract:
The present invention relates to a process for producing an optically active (2S,3S)-3- hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one (Cis-lactam). More particularly, this invention relates to a process for making (2R,3S)-3-(4- methoxyphenyl)glycidic acid methyl ester employing enzymes, which is simple, industrially applicable and economically viable.
Inventors:
HUSAIN MOFAZZAL (IN)
CHAUHAN YOGENDRA (IN)
CHAUHAN YOGENDRA (IN)
Application Number:
PCT/IB2013/056675
Publication Date:
July 10, 2014
Filing Date:
August 16, 2013
Export Citation:
Assignee:
UNIMARK REMEDIES LTD (IN)
International Classes:
C12P7/40; C07C59/64; C07D281/10; C07D303/02; C12P7/62; C12P17/02; C12P17/14; C12P41/00
Domestic Patent References:
| WO1990004643A1 | 1990-05-03 |
Other References:
WANG, Y. ET AL.: "Significantly Improved Expression and Biochemical Properties of Recombinant Serratia marcescens Lipase as Robust Biocatalyst for Kinetic Resolution of Chiral Ester", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 162, no. 8, December 2010 (2010-12-01), pages 2387 - 2399, XP002720358
ZHAO, L.L. ET AL.: "Biochemical properties and potential applications of an organic solvent-tolerant lipase isolated from Serratia marcescens ECU1010", PROCESS BIOCHEMISTRY, vol. 43, no. 6, June 2008 (2008-06-01), pages 626 - 633, XP022637311
ZHAO, L.L. ET AL.: "Biochemical properties and potential applications of an organic solvent-tolerant lipase isolated from Serratia marcescens ECU1010", PROCESS BIOCHEMISTRY, vol. 43, no. 6, June 2008 (2008-06-01), pages 626 - 633, XP022637311
Attorney, Agent or Firm:
NAIR, Manisha Singh (709/710 Tolstoy House,15 - 17, Tolstoy Marg, New Delhi 1, IN)
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