Title:
PROCESS FOR PRODUCING 3-ACYLAMINOBENZOFURAN-2-CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/000839
Kind Code:
A1
Abstract:
An excellent process for efficiently producing a benzofuran derivative or pyridofuran derivative or a pharmacologically acceptable salt of either, the derivatives being represented by the general formula [I]: [I] (wherein X represents -N= or -CH=; R1 represents hydrogen, halogeno, lower alkyl, lower alkoxy, cyano, or amino optionally substituted by lower alkyl; ring A represents a nitrogenous heterocyclic group; ring B represents an optionally substituted benzene ring or pyridine ring; and R3 represents hydrogen or lower alkyl). The derivatives are useful as an inhibitor against an activated blood coagulation factor X.
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Inventors:
SEKI MASAHIKO (JP)
YOSHIDA SHIN-ICHI (JP)
YAGI NOBUHIRO (JP)
HATSUDA MASANORI (JP)
KIMURA MAYUMI (JP)
KONDO KAZUHIKO (JP)
YOSHIDA SHIN-ICHI (JP)
YAGI NOBUHIRO (JP)
HATSUDA MASANORI (JP)
KIMURA MAYUMI (JP)
KONDO KAZUHIKO (JP)
Application Number:
PCT/JP2004/009488
Publication Date:
January 06, 2005
Filing Date:
June 29, 2004
Export Citation:
Assignee:
TANABE SEIYAKU CO (JP)
SEKI MASAHIKO (JP)
YOSHIDA SHIN-ICHI (JP)
YAGI NOBUHIRO (JP)
HATSUDA MASANORI (JP)
KIMURA MAYUMI (JP)
KONDO KAZUHIKO (JP)
SEKI MASAHIKO (JP)
YOSHIDA SHIN-ICHI (JP)
YAGI NOBUHIRO (JP)
HATSUDA MASANORI (JP)
KIMURA MAYUMI (JP)
KONDO KAZUHIKO (JP)
International Classes:
C07C209/04; C07C211/45; C07C227/16; C07C229/48; C07C253/14; C07C255/49; C07D207/27; C07D211/76; C07D213/57; C07D265/32; C07D333/62; C07D405/12; C07D405/14; C07D413/14; C07D213/81; C07D213/85; C07D307/85; C07D333/68; (IPC1-7): C07D405/14; C07D405/12; C07C229/48; C07C227/16; C07C211/45; C07C209/04; C07C253/14; C07C255/49
Domestic Patent References:
| WO1999014191A1 | 1999-03-25 |
Foreign References:
| JPS57122062A | 1982-07-29 | |||
| JP2001039938A | 2001-02-13 |
Other References:
DJAKOVITCH L. ET AL.: "Amination of aryl bromides catalysed by supported palladium", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 592, no. 2, 1999, pages 225 - 234, XP002982248
INGOLD K.U. ET AL.: "Cycloalkylmethyl radicals. Part 3. Dynamic stereochemistry of axial and equatorial cyclohexylmethyl and 4-alkylcyclohexylmethyl radicals", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS II, no. 8, 1986, pages 1337 - 1344, XP002982249
VITI G. ET AL.: "Synthesis of new arylbenzofurodiazepin-6-ones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, no. 5, 1990, pages 1369 - 1375, XP002962139
HARRISON C.R. ET AL.: "Preparation of alkyl chlorides, acid chlorides, and amides using polymer-supported phosphines and carbon tetrachloride: mechanism of these reactions", J. ORG. CHEM., vol. 48, no. 21, 1983, pages 3721 - 3728, XP002982250
See also references of EP 1640373A4
INGOLD K.U. ET AL.: "Cycloalkylmethyl radicals. Part 3. Dynamic stereochemistry of axial and equatorial cyclohexylmethyl and 4-alkylcyclohexylmethyl radicals", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS II, no. 8, 1986, pages 1337 - 1344, XP002982249
VITI G. ET AL.: "Synthesis of new arylbenzofurodiazepin-6-ones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, no. 5, 1990, pages 1369 - 1375, XP002962139
HARRISON C.R. ET AL.: "Preparation of alkyl chlorides, acid chlorides, and amides using polymer-supported phosphines and carbon tetrachloride: mechanism of these reactions", J. ORG. CHEM., vol. 48, no. 21, 1983, pages 3721 - 3728, XP002982250
See also references of EP 1640373A4
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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