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Patent Searching and Data


Title:
PROCESS FOR PRODUCING 3-SUBSTITUTED THIO-3-CEPHEM COMPOUND
Document Type and Number:
WIPO Patent Application WO/1991/009037
Kind Code:
A1
Abstract:
A 7-acylamido-3-substituted thio-3-cephem-4-carboxylic ester of general formula (5) can be produced preferentially, readily and efficiently by reacting 7-acylamido-3-acylthio-3- or 2-cephem-4-carboxylic ester of general formula (1) (wherein R1 represents acyl, R2 represents a protective group of the carboxyl group, and R3 represents lower alkyl or (un)substituted aryl) or a mixture thereof with tertiary and secondary amines and further reacting a tertiary amine salt of the reaction product with a compound of general formula (4): R4-X, wherein R4 represents lower alkyl, cycloalkyl, heterocycle or heterocycle-substituted methyl and X represents a leaving group.

Inventors:
YAMAMOTO YUICHI (JP)
OKONOGI TSUNEO (JP)
SHIBAHARA SEIJI (JP)
INOUE SHIGEHARU (JP)
Application Number:
PCT/JP1990/001599
Publication Date:
June 27, 1991
Filing Date:
December 07, 1990
Export Citation:
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Assignee:
MEIJI SEIKA KAISHA (JP)
International Classes:
C07D501/00; C07D501/04; C07D501/59; (IPC1-7): C07D501/04
Foreign References:
JPH01128986A1989-05-22
JPS62267228A1987-11-19
Other References:
See also references of EP 0504404A4
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